Anti-myostatin antibodies, polypeptides containing variant Fc regions, and methods of use

  • US 10,738,111 B2
  • Filed: 04/26/2018
  • Issued: 08/11/2020
  • Est. Priority Date: 12/19/2014
  • Status: Active Grant
First Claim
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1. A method of increasing at least one of mass of muscle tissue and strength of muscle tissue in an individual comprising administering to the individual an effective amount of an antibody that binds latent myostatin to increase at least one of mass of muscle tissue and strength of muscle tissue;

  • wherein the antibody comprises;

    (a) a HVR-H1 comprising the amino acid sequence X1X2DIS (SEQ ID NO;

         126), wherein X1 is S or H, X2 is Y, T, D or E;

    (b) a HVR-H2 comprising the amino acid sequence IISX1AGX2X3YX4X5X6WAKX7 (SEQ ID NO;

         127), wherein X1 is Y or H, X2 is S or K, X3 is T, M or K, X4 is Y or K, X5 is A, M or E, X6 is S or E, X7 is G or K;

    (c) a HVR-H3 comprising the amino acid sequence GVPAX1SX2GGDX3 (SEQ ID NO;

         128), wherein X1 is Y or H, X2 is T or H, X3 is L or K;

    (d) a HVR-L1 comprising the amino acid sequence X1X2SQX3VX4X5X6NWLS (SEQ ID NO;

         129), wherein X1 is Q or T, X2 is S or T, X3 is S or E, X4 is Y or F, X5 is D or H, X6 is N, D, A or E;

    (e) a HVR-L2 comprising the amino acid sequence WAX1TLAX2 (SEQ ID NO;

         130), wherein X1 is S or E, X2 is S, Y, F or W; and

    (f) a HVR-L3 comprising the amino acid sequence AGGYGGGX1YA (SEQ ID NO;

         131), wherein X1 is L or R.

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