System and method for motor and cognitive analysis

• US 10,741,287 B2
• Filed: 10/04/2012
• Issued: 08/11/2020
• Est. Priority Date: 11/19/2009
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Alberts, Jay L., McIntyre, Cameron
• Primary Examiner(s): Henson, Devin B
• Application Number:
  US13/644,344
• Publication Number:
  US 20140074267A1
• Time in Patent Office: 2,868 Days
• Field of Search: 600300, 600301, 600558, 600559
• CPC Class Codes: A61B 2562/0219 Inertial sensors, e.g. accelerometers, gyroscopes, tilt switches
• CPC Class Codes: A61B 5/1106 to assess neuromuscular blockade, e.g. to estimate depth of anaesthesia
• CPC Class Codes: A61B 5/1116 Determining posture transitions
• CPC Class Codes: A61B 5/1118 Determining activity level
• CPC Class Codes: A61B 5/1124 Determining motor skills
• CPC Class Codes: A61B 5/16 Devices for psychotechnics using teaching or educational appliances G09B1/00 - G09B7/00; Testing reaction times ; Devices for evaluating the psychological state
• CPC Class Codes: A61B 5/162 Testing reaction times
• CPC Class Codes: A61B 5/4082 Diagnosing or monitoring movement diseases, e.g. Parkinson, Huntington or Tourette
• CPC Class Codes: A61B 5/4833 Assessment of subject's compliance to treatment
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 50/20 for computer-aided diagnosis, e.g. based on medical expert systems
• CPC Class Codes: G16H 50/30 for calculating health indices; for individual health risk assessment
• CPC Class Codes: G16H 50/70 for mining of medical data, e.g. analysing previous cases of other patients

Abstract

In an example embodiment, this disclosure provides a non-transitive computer-readable medium on which are stored instructions executable by a processor, the instructions which, when executed by the processor, cause the processor to perform a method. The method includes computing, based on test performance data of a user, at least one of a performance variable characterizing cognitive functioning and a performance variable characterizing neuromotor functioning. For each of the at least one performance variable, a respective score can be computed based on the respective performance variable and based on a set of performance metrics. The method can also include outputting, via an output device, the at least one computed score.

Claims

1. A computer system, comprising:

a computer processor; and

a graphical user interface configured to display an output and receive a user input;

wherein the processor is configured to;

configure a display for a test based on a display size of the graphical user interface wherein the display size of the graphical user interface is determined based on a calibration procedure comprising user interaction with the graphical user interface and an external article of known dimension;

display, on the graphical user interface, at least two target graphical test objects of a set of target graphical test objects scaled according to the configured display for the test;

receive an input comprising user position data from the graphical user interface, wherein the user position data corresponds to a plurality of user positions related to a path between the at least two target graphical test objects on the graphical user interface;

record respective time information for each of the plurality of user positions during the test;

compute, based on the user position data and the respective time data, a dwell time for a portion of the plurality of user positions during the test;

compute a preliminary score based on the dwell time for each of the portion of the plurality of positions, the preliminary score characterizing at least one of a motor function of the user, a cognitive function of the user, and a cognitive-motor function of the user during the test;

adjust a display property of the set of target graphical test objects related to a difficulty of the test based on the preliminary score prior to completion of the test;

display, on the graphical user interface at least a portion of the set of target graphical test objects with the adjusted display property and scaled according to the configured display during the test;

continue conducting the test with at least the portion of the set of target graphical test objects with the adjusted display property;

compute a final score characterizing at least one of a motor function of the user, a cognitive function of the user, and a cognitive-motor function of the user after completion of the test; and

output, on the graphical user interface, the computed final score for the test and an analysis related to the computed final score.

2. The system of claim 1, wherein the processor computes separate final scores respectively characterizing motor function and cognitive function.

3. The system of claim 1, wherein the processor computes a composite final score characterizing a cognitive-motor function.

4. The system of claim 1, wherein the computation of the final score includes a weighting based on performance of a plurality of patients of a patient population.

5. The system of claim 1, wherein the computed preliminary score is further based on kinematic data obtained from the user position data.

6. The system of claim 5, wherein the processor is configured to compute the preliminary score based on an error value indicative of a difference between the kinematic data and ideal kinematic data.

7. The system of claim 1, wherein the processor is configured to compute an error value based on a difference between a line drawn to connect one of the at least two target graphical test objects and another of the at least two target graphical test objects and an ideal line connecting the at least two target graphical test objects, the line drawn corresponding to the path based on the user position data.

8. The system of claim 1, wherein the processor is configured to compute a reaction time between presentation of a stimulus and at least one of the plurality of user positions, wherein the preliminary score is based on the reaction time.

9. The system of claim 1, wherein the processor is configured to select, from a plurality of tests, a second test of the plurality of tests to administer based on a relationship between the computed preliminary score and the computed final score and respective difficulties of the plurality of tests.

10. The system of claim 1, wherein the system is configured to:

receive an input of a proposed change in medical treatment for the user;

search a patient database for patients with clinical characteristics and scores similar to those of the user;

search the patient database for those of the similar patients who have been subjected to a change similar to the proposed change; and

based on data stored in association with the patients subjected to the similar change, determine an expected change, in response to the proposed change, in at least one of the computed preliminary score for the user, the computed final score for the user, and medical condition classification for the user.

11. The system of claim 1, wherein the graphical user interface is configured to be one of attached to and held by the user during administration of the test, wherein the test provides the user position data.

12. The system of claim 1, wherein the computed preliminary score and/or the computed final score characterizing a cognitive function of the user are computed, the computation of the preliminary score and/or the final score being based on test data obtained via at least one of a Sport Concussion Assessment Tool (SCAT) test, a working memory test, a set-switching test and a delayed recognition test.

13. The system of claim 1, wherein the computed preliminary score and/or the computed final score characterizing a motor function of the user are computed, the computations being based on data obtained via at least one of a simple reaction time (SRT) test and a choice reaction time (CRT) test.

14. The system of claim 1, wherein the dwell time is computed for user positions within a bounded area that encompasses at least one of the at least two target graphical test objects.

15. The system of claim 1, wherein the user position data is further related to straightness of movement.

16. The system of claim 1, wherein the display property is adjusted during the administration of the test to include at least one of a size of the target graphical test objects, a distance between respective target graphical test objects, and a moving or stationary state of the graphical test objects.

17. The system of claim 1, wherein the external article comprises a sheet of paper, a dollar bill or a credit card.

18. The system of claim 1, wherein the set of target graphical test objects remains the same during the test.

19. A computer-implemented method comprising:

configuring, by a computer processor, a display of a display device, based on a calibration procedure comprising user interaction with the display device and an external article of known dimensions;

displaying, by the computer processor on the display device, a test display comprising at least two target graphical test objects of a set of target graphical test objects scaled according to the configured display of the display device for a test;

receiving, by the computer processor, an input comprising user position data from an input device corresponding to a plurality of user positions related to a path between the at least two target graphical test objects;

recording, by the computer processor, respective time information for each of the plurality of user positions during the test;

computing, by the processor and based on the user position data and the respective time information, a dwell time for a portion of the plurality of user positions during the test;

computing, by the processor and based on the dwell time, a preliminary score for each of the portion of the plurality of positions, the preliminary score characterizing at least one of a motor function of the user, a cognitive function of the user, and a cognitive-motor function of the user during the test;

adjusting, by the processor, a display property of the set of target graphical test objects related to a difficulty of the test based on the preliminary score prior to completion of the test;

displaying, by the processor, on the display, at least a portion of the set of target graphical test objects with the adjusted display property and scaled according to the display of the display device during the test;

continuing to conduct, by the processor, the test with at least the portion of the set of target graphical test objects with the adjusted display property;

computing, by the processor, a final score characterizing at least one of a motor function of the user, a cognitive function of the user, and a cognitive-motor function of the user after completion of the test; and

outputting, by the computer processor on the display device, the computed final score for the test and an analysis related to the computed final score.

20. The method of claim 19, wherein the dwell time is computed for user positions within a bounded area that encompasses at least one of the at least two target graphical test objects.

21. A non-transitory computer-readable medium on which are stored instructions executable by a processor, the instructions which, when executed by the processor, cause the processor to perform a method, the method comprising:

configuring a display of a display device, based on a calibration procedure comprising user interaction with the display device and an external article of known dimensions;

displaying on the configured display of the display device at least two target graphical test objects of a set of target graphical test objects scaled according to a display of the display device for a test;

receiving an input comprising user position data from an input device corresponding to a plurality of user positions related to a path between the at least two target graphical test objects;

recording respective time information for each of the plurality of user positions during the test;

computing, based on the user position data and the respective time data, a dwell time for a portion of the plurality of user positions during the test;

computing based on the dwell time, a preliminary score for each of the portion of the plurality of positions, the preliminary score characterizing at least one of a motor function of the user, a cognitive function of the user, and a cognitive-motor function of the user during the test;

adjusting a display property of the set of target graphical test objects related to a difficulty of the test based on the preliminary score prior to completion of the test;

displaying on the display graphical user interface at least a portion of the set of target graphical test objects with the adjusted display property and scaled according to the configured display during the test;

continuing to conduct the test at least the portion of the set of target graphical test objects with the adjusted display property;

computing a final score characterizing at least one of a motor function of the user, a cognitive function of the user, and a cognitive-motor function of the user after completion of the test; and

outputting, via an output device, the computed final score for the test and an analysis related to the computed final score.

22. The medium of claim 21, the instructions, when executed by the processor, further cause the processor to compute the dwell time for user positions within a bounded area that encompasses at least one of the at least two target graphical test objects, the preliminary score being computed based on the dwell time in relation to historical data for at least one of the user, a static population, or a dynamic population,

wherein the historical data is stored in a database.