Implants using ultrasonic waves for stimulating tissue

• US 10,744,347 B2
• Filed: 05/01/2019
• Issued: 08/18/2020
• Est. Priority Date: 07/07/2016
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Maharbiz, Michel M., Seo, Dongjin, Shen, Konlin, Carmena, Jose M., Neely, Ryan, Alon, Elad, Rabaey, Jan
• Primary Examiner(s): Chao, Elmer M
• Application Number:
  US16/401,028
• Publication Number:
  US 20200114175A1
• Time in Patent Office: 475 Days
• CPC Class Codes: A61B 2505/05 Surgical care
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 2562/12 Manufacturing methods specially adapted for producing sensors for in-vivo measurements
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/076 Permanent implantations telemetry using implanted circuitry A61B5/0031; implanted stimulators for therapy A61N1/3605, A61N1/362, A61N1/372
• CPC Class Codes: A61B 5/279 specially adapted for particular uses
• CPC Class Codes: A61B 5/686 Permanently implanted devices, e.g. pacemakers, other stimulators, biochips A61B5/6861 takes precedence
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61B 8/0808 for diagnosis of the brain
• CPC Class Codes: A61B 8/085 for locating body or organic structures, e.g. tumours, calculi, blood vessels, nodules
• CPC Class Codes: A61B 8/0875 for diagnosis of bone A61B5/4504 takes precedence
• CPC Class Codes: A61B 8/48 Diagnostic techniques A61B8/13 takes precedence
• CPC Class Codes: A61M 2205/04 implanted
• CPC Class Codes: A61M 2205/825 using mechanical generation of electricity, e.g. hand cranked generators
• CPC Class Codes: A61M 39/0208 Subcutaneous access sites for injecting or removing fluids transcutaneous access sites A61M39/0247; implantable infusion devices A61M5/14276
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/3787 : from an external energy source
• CPC Class Codes: A61N 2005/1087 : Ions; Protons
• CPC Class Codes: A61N 2007/0021 : Neural system treatment
• CPC Class Codes: A61N 5/1071 : for verifying the dose delivered by the treatment plan
• CPC Class Codes: B06B 1/06 : operating with piezoelectric effect or with electrostriction piezoelectric or electrostrictive devices per se H10N30/00
• CPC Class Codes: G01N 27/327 : Biochemical electrodes , e.g. electrical or mechanical details for in vitro measurements

Abstract

Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal. Further described are computer systems useful for operating one or more implantable devices, as well as methods of electrically stimulating a tissue.

Claims

1. A closed-loop system, comprising:

(a) an implantable device configured to detect a physiological signal and emit an electrical pulse in response to a trigger signal, comprising;

(i) a sensor configured to detect the physiological signal;

(ii) an energy storage circuit;

(iii) an integrated circuit comprising a modulation circuit configured to modulate a current based on the detected physiological signal;

(iv) an ultrasonic transducer configured to receive ultrasonic waves and configured to emit ultrasonic backscatter waves encoding information related to the physiological signal based on the modulated current, wherein the received ultrasonic waves power the implantable device and encode the trigger signal; and

(v) a first electrode and a second electrode configured to be in electrical communication with a tissue and emit the electrical pulse to the tissue in response to the trigger signal; and

(b) an interrogator comprising one or more ultrasonic transducers configured to receive the ultrasonic backscatter encoding the information related to the physiological signal, and emit ultrasonic waves encoding the trigger signal.

2. The system of claim 1, wherein the physiological signal comprises an electrophysiological signal.

3. The system of claim 1, wherein the physiological signal comprises a temperature.

4. The system of claim 1, wherein the physiological signal comprises an analyte concentration.

5. The system of claim 1, wherein the physiological signal comprises a pH.

6. The system of claim 1, wherein the physiological signal comprises pressure, strain, or bioimpedance.

7. The system of claim 2, wherein the sensor comprises a first sensor electrode and a second sensor electrode configured to be in electrical communication with the tissue.

8. The system of claim 1, wherein the first electrode and the second electrode of the implantable device are within the tissue or contact the tissue.

9. The system of claim 1, wherein the integrated circuit of the implantable device comprises a digital circuit.

10. The system of claim 1, wherein the integrated circuit of the implantable device comprises a mixed-signal integrated circuit configured to operate the first electrode and the second electrode.

11. The system of claim 1, wherein the integrated circuit comprises a power circuit comprising the energy storage circuit.

12. The system of claim 1, wherein the tissue is muscle tissue or an organ.

13. The system of claim 1, wherein the tissue is nervous tissue.

14. The system of claim 1, wherein the implantable device is implanted in a subject.

15. The system of claim 1, wherein the interrogator is wearable by a subject.

16. A method of stimulating a tissue, comprising:

receiving ultrasonic waves at an implantable device configured to detect a physiological signal and emit an electrical pulse to the tissue;

converting, at the implantable device, energy from the ultrasonic waves into an electrical current that flows through a modulation circuit;

detecting, at the implantable device, the physiological signal;

producing, at the implantable device, a modulated electrical current based on the detected physiological signal;

transducing, at the implantable device, the modulated electrical current into an ultrasonic backscatter that encodes information related to the detected physiological signal; and

emitting, from the implantable device, the ultrasonic backscatter that encodes the information related to the detected physiological signal;

receiving, at an interrogator comprising one or more ultrasonic transducers, the ultrasonic backscatter that encodes the information related to the detected physiological signal;

emitting, from the interrogator, ultrasonic waves configured to power the implantable device;

receiving, at the implantable device, the ultrasonic waves configured to power the implantable device;

converting, at the implantable device, energy from the ultrasonic waves configured to power the implantable device into an electrical current that charges an energy storage circuit of the implantable device;

emitting, from the interrogator, ultrasonic waves encoding a trigger signal;

receiving, at the implantable device, the ultrasonic waves encoding the trigger signal; and

emitting, from the implantable device, an electrical pulse that stimulates the tissue in response to the trigger signal.

17. The method of claim 16, wherein the physiological signal comprises an electrophysiological signal.

18. The method of claim 16, wherein the physiological signal comprises a temperature.

19. The method of claim 16, wherein the physiological signal comprises an analyte concentration.

20. The method of claim 16, wherein the physiological signal comprises a pH.

21. The method of claim 16, wherein the physiological signal comprises pressure, strain, or bioimpedance.

22. The method of claim 17, wherein the sensor comprises a first sensor electrode and a second sensor electrode configured to be in electrical communication with the tissue.

23. The method of claim 16, wherein the tissue comprises muscle tissue or an organ.

24. The method of claim 16, wherein the tissue comprises nervous tissue.

25. The method of claim 16, wherein the implantable device is implanted in a subject.

26. The method of claim 25, wherein the interrogator worn by the subject.

27. The method of claim 25, wherein the subject is a human.