Polymorphic mixture of Rifaximin and its use for the preparation of solid formulations

  • US 10,745,415 B2
  • Filed: 09/11/2019
  • Issued: 08/18/2020
  • Est. Priority Date: 03/31/2014
  • Status: Active Grant
First Claim
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1. A method of treating a subject suffering from traveler'"'"'s diarrhea comprising:

  • selecting a subject in need of treatment of traveler'"'"'s diarrhea;

    administering to said subject a pharmaceutical composition comprising a therapeutically effective amount of Rifaximin in an α



    polymorphic mixture of 85/15±

    3 in an amount sufficient to treat the traveler'"'"'s diarrhea, wherein the Rifaximin α



    polymorphic mixture is characterized by an X-Ray spectrum with characteristic 2theta values at;

    5.32, 5.78, 6.50, 7.24, 7.82, 8.80, 10.50, 11.02, 11.58, 13.08, 14.42, 17.32, 17.68, 18.58, 19.52, 21.04, 21.60, and 21.92.

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