Systems and methods for ex vivo lung care
First Claim
1. A method of measuring reoxygenation time of an ex-vivo human lung, the method comprising:
- circulating a perfusion fluid through the ex-vivo lung, the perfusion fluid entering the ex-vivo lung through a pulmonary artery interface and leaving the ex-vivo lung through a left atrial interface;
ventilating the ex-vivo lung by flowing a ventilation gas through a tracheal interface;
deoxygenating the perfusion fluid until a predetermined first value of oxygen content in the perfusion fluid is reached;
holding the perfusion fluid at the predetermined first value of the oxygen content;
halting ventilation or initiating a purge cycle;
reoxygenating the perfusion fluid by ventilating the ex-vivo lung with an oxygenation gas until a predetermined second value of the oxygen content in the perfusion fluid is reached; and
measuring an ex-vivo lung reoxygenation time as a time taken for the ex-vivo lung to cause the oxygen content in the perfusion fluid to change from the predetermined first value of the oxygen content to the predetermined second value of the oxygen content.
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Abstract
Methods and systems of maintaining, evaluating, and providing therapy to a lung ex vivo. The methods and systems involve positioning the lung in an ex vivo perfusion circuit; circulating a perfusion fluid through the lung, the fluid entering the lung through a pulmonary artery interface and leaving the lung through a left atrial interface; and ventilating the lung by flowing a ventilation gas through a tracheal interface. Maintaining the lung for extended periods involves causing the lung to rebreath a captive volume of air, and reaching an equilibrium state between the perfusion fluid and the ventilation gas. Evaluating the gas exchange capability of the lung involves deoxygenating the perfusion fluid and measuring a time taken to reoxygenate the perfusion fluid by ventilating the lung with an oxygenation gas.
251 Citations
19 Claims
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1. A method of measuring reoxygenation time of an ex-vivo human lung, the method comprising:
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circulating a perfusion fluid through the ex-vivo lung, the perfusion fluid entering the ex-vivo lung through a pulmonary artery interface and leaving the ex-vivo lung through a left atrial interface; ventilating the ex-vivo lung by flowing a ventilation gas through a tracheal interface; deoxygenating the perfusion fluid until a predetermined first value of oxygen content in the perfusion fluid is reached; holding the perfusion fluid at the predetermined first value of the oxygen content; halting ventilation or initiating a purge cycle; reoxygenating the perfusion fluid by ventilating the ex-vivo lung with an oxygenation gas until a predetermined second value of the oxygen content in the perfusion fluid is reached; and measuring an ex-vivo lung reoxygenation time as a time taken for the ex-vivo lung to cause the oxygen content in the perfusion fluid to change from the predetermined first value of the oxygen content to the predetermined second value of the oxygen content. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification