Method and apparatus for calibration to reduce coupling between signals in a measurement system

• US 10,772,542 B2
• Filed: 12/07/2017
• Issued: 09/15/2020
• Est. Priority Date: 10/12/2006
• Status: Active Grant

• Current Assignee: Masimo Corporation
• Original Assignee: Masimo Corporation
• Inventors: Weber, Walter M., Al-Ali, Ammar, Diab, Mohamed K., Lamego, Marcelo M.
• Primary Examiner(s): Winakur, Eric F
• Assistant Examiner(s): Liu, Chu Chuan
• Application Number:
  US15/834,965
• Publication Number:
  US 20180153448A1
• Time in Patent Office: 1,013 Days
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2562/0238 Optical sensor arrangements for performing transmission measurements on body tissue
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/7228 Signal modulation applied to the input signal sent to patient or subject; demodulation to recover the physiological signal modulation H03C

Abstract

A method and an apparatus for separating a composite signal into a plurality of signals is described. A signal processor receives a composite signal and separates a composite signal into separate output signals. Feedback from one or more of the output signals is provided to a configuration module that configures the signal processor to improve a quality of the output signals. In one embodiment, calibration data from multiple calibration data sets is used to configure the demodulation of the composite signal into separate output signals.

Claims

1. An apparatus for measuring one or more blood constituents in a subject, said apparatus comprising:

a first signal source which applies a first input signal during a first time interval;

a second signal source which applies a second input signal during a second time interval;

a third signal source which applies a third input signal during a third time interval;

a detector which detects a first parametric signal responsive to said first input signal passing through a portion of said subject having blood therein, a second parametric signal responsive to said second input signal passing through said portion of said subject, and a third parametric signal responsive to said third input signal passing through a portion of said subject having blood therein, said detector generating a detector output signal responsive to said first, second, and third parametric signals; and

a signal processor which receives said detector output signal, said signal processor configured to demodulate said detector output signal by applying a first demodulation signal to a signal responsive to said detector output signal to generate a first demodulator output signal, applying a second demodulation signal to said signal responsive to said detector output signal to generate a second demodulator output signal, and applying a third demodulation signal to said signal responsive to said detector output signal to generate a third demodulator output signal, said signal processor configured to select said first demodulation signal, said second demodulation signal and said third demodulation signal to reduce crosstalk between said first, second, and third parametric signals using, at least in part, first and second calibration data, wherein said first calibration data comprises calibration data wherein said first signal source, said second signal source, and said third signal source are operated singly during a normal operation period, and wherein said second calibration data comprises calibration data wherein said first signal source, said second signal source, and said third signal source are operated in pairs during a normal operation period where only one light source is on at any time.

2. An apparatus for measuring one or more parameters in a subject, said apparatus comprising:

three or more sources;

at least one detector configured to sense electromagnetic radiation produced by said three or more sources, an output of said at least one detector comprising a detector signal; and

a signal processor which receives said detector output signal, said signal processor configured to demodulate said detector output signal by applying a first demodulation signal to a signal responsive to said detector output signal to generate a first demodulator output signal, applying a second demodulation signal to said signal responsive to said detector output signal to generate a second demodulator output signal, and applying a second demodulation signal to said signal responsive to said detector output signal to generate a third demodulator output signal, said signal processor configured to select said first demodulation signal, said second demodulation signal and said third demodulation signal to reduce crosstalk between said first, second, and third demodulator signals using, at least in part, calibration data, wherein said calibration data is obtained, at least in part, by activating said three or more sources according to a set of activation patterns, wherein the number of activation patterns is greater than the number of sources in said three or more sources.

3. The apparatus of claim 2, wherein said activation patterns comprise a first set of patterns wherein each of said three or more sources is activated singly, and a second set of patterns wherein each of said three or more sources is deactivated singly.

4. The apparatus of claim 2, wherein said activation patterns comprise patterns wherein each of said three or more sources is activated one at a time.

5. The apparatus of claim 2, wherein said activation patterns comprise patterns wherein each of said three or more sources is de-activated one at a time.

6. An apparatus for measuring one or more blood constituents in a subject, said apparatus comprising:

a first signal source which applies a first input signal during a first time interval;

a second signal source which applies a second input signal during a second time interval;

a third signal source which applies a third input signal during a third time interval;

a detector which detects a first parametric signal responsive to said first input signal passing through a portion of said subject having blood therein and which detects a second parametric signal responsive to said second input signal passing through said portion of said subject, and a third parametric signal responsive to said third input signal, said detector generating a detector output signal responsive to said first, second, and third parametric signals; and

a signal processor which receives said detector output signal, said signal processor demodulating said detector output signal by applying a first demodulation signal to a signal responsive to said detector output signal to generate a first demodulator output signal and applying a second demodulation signal to said signal responsive to said detector output signal to generate a second demodulator output signal, said first demodulation signal determined at least in part from a first dataset wherein each of said first, second, and third sources are activated one at a time and a second dataset wherein each of said first, second, and third sources are deactivated one at a time.

7. The apparatus of claim 6, wherein at least a portion of said first dataset comprises turning on only one of said first, second, or third signal sources and measuring a crosstalk between one of the first, second, and third parametric signals and non-corresponding output signals.

8. The apparatus of claim 6, wherein at least a portion of said first dataset comprises turning off only one of said first, second, or third signal sources and measuring a crosstalk between one of the first, second, and third parametric signals and non-corresponding output signals.

9. The apparatus of claim 6, wherein at least a portion of said first dataset comprises a set of activation patterns wherein less than half of said first, second, and third signal sources are active in each pattern.

10. The apparatus of claim 6, wherein at least a portion of said first dataset comprises a set of activation patterns wherein more than half of said first, second, and third signal sources are active in each pattern.

11. The apparatus of claim 6, further comprising a fourth signal source and wherein at least a portion of said first dataset comprises a set of unique activation patterns wherein a plurality of said first, second, third and fourth signal sources are active and a plurality of said first, second, third and fourth sources are not active in each pattern.

12. The apparatus of claim 6, further comprising a fourth signal source and a fifth signal source and wherein at least a portion of said first dataset is obtained using a set of activation patterns wherein a plurality of said first, second, third, fourth and fifth signal sources are active and a plurality of said first, second, third, fourth and fifth signal sources are not active in each pattern and where each activation pattern is different.