Methods and systems for modifying bioactive agent use

• US 10,786,626 B2
• Filed: 11/11/2016
• Issued: 09/29/2020
• Est. Priority Date: 04/24/2008
• Status: Active Grant

• Current Assignee: Harvest Bio LLC
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Ishikawa, Muriel Y., Leuthardt, Eric C., Levien, Royce A., Lord, Robert W., Malamud, Mark A., Sweeney, Elizabeth A., Wood, Jr., Lowell L., Wood, Victoria Y. H.
• Primary Examiner(s): Fleischer, Mark A
• Application Number:
  US15/349,974
• Publication Number:
  US 20170100540A1
• Time in Patent Office: 1,418 Days
• CPC Class Codes: A61B 5/024 Detecting, measuring or recording pulse rate or heart rate A61B5/0205, A61B5/021 take precedence
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/16 Devices for psychotechnics using teaching or educational appliances G09B1/00 - G09B7/00; Testing reaction times ; Devices for evaluating the psychological state
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/411 Detecting or monitoring allergy or intolerance reactions to an allergenic agent or substance
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61B 5/4266 sweat secretion
• CPC Class Codes: A61B 5/48 Other medical applications
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2205/502 User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/52 with memories providing a history of measured variating parameters of apparatus or patient
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/10 Electroencephalographic signals
• CPC Class Codes: A61M 2230/30 Blood pressure A61M2230/04 takes precedence
• CPC Class Codes: A61M 2230/65 Impedance, e.g. conductivity, capacity
• CPC Class Codes: A61M 5/1723 : using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G06F 16/24575 : using context
• CPC Class Codes: G06F 3/011 : Arrangements for interaction with the human body, e.g. for user immersion in virtual reality blind teaching G09B21/00
• CPC Class Codes: G16H 20/10 : relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 40/20 : for the management or administration of healthcare resources or facilities, e.g. managing hospital staff or surgery rooms

Abstract

Methods, computer program products, and systems are described that include measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and/or modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect.

Claims

1. A method, comprising:

measuring, via one or more processors, at least one effect of a combined bioactive agent and artificial sensory experience on an individual; and

modifying, via the one or more processors, at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect, comprising;

modifying, via the one or more processors, a bioactive agent dosage; and

transmitting, via the one or more processors, a modified bioactive agent dosage signal based on the modified bioactive agent dosage to an administration unit configured to administer the modified bioactive agent dosage to the individual.

2. The method of claim 1, wherein the measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual comprises:

measuring the at least one effect at least one of during or after the individual experiences the combined bioactive agent and artificial sensory experience.

3. The method of claim 1, wherein the measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual comprises:

measuring the at least one effect with a self-assessment.

4. The method of claim 1, wherein the measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual comprises:

measuring the at least one effect with a computerized assessment.

5. The method of claim 1, wherein the measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual comprises:

measuring an expected behavior.

6. The method of claim 1, wherein the modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect comprises:

modifying access to at least a portion of the artificial sensory experience to alter at least one effect of the bioactive agent.

7. The method of claim 1, wherein the modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect comprises:

modifying a visual object in an artificial sensory experience to alter at least one effect of the bioactive agent.

8. The method of claim 7, wherein the modifying a visual object in an artificial sensory experience to alter at least one effect of the bioactive agent comprises:

modifying a color scheme of an artificial sensory experience to alter at least one effect of the bioactive agent.

9. The method of claim 7, wherein the modifying a visual object in an artificial sensory experience to alter at least one effect of the bioactive agent comprises:

modifying at least a portion of text of an artificial sensory experience to alter at least one effect of the bioactive agent.

10. The method of claim 1, wherein the modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect comprises:

altering a sound in an artificial sensory experience.

11. The method of claim 10, wherein the altering a sound in an artificial sensory experience comprises:

altering at least a portion of music in the artificial sensory experience.

12. The method of claim 10, wherein the altering a sound in an artificial sensory experience comprises:

altering at least a portion of ambient noise in the artificial sensory experience.

13. The method of claim 10, wherein the altering a sound in an artificial sensory experience comprises:

altering at least a portion of voice in the artificial sensory experience.

14. The method of claim 1, wherein the modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect comprises:

adding or deleting at least one of visual or audio content to the artificial sensory experience.

15. The method of claim 1, wherein the modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect comprises:

modifying a sensate experience to alter the at least one effect of the bioactive agent.

16. The method of claim 1, wherein the measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and the modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect comprise:

measuring at least one effect of a pain medication and modifying a virtual world experience to alter at least one effect of the pain medication.

17. The method of claim 1, wherein the measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual and the modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect comprise:

measuring at least one effect of an anti-depressant medication prescribed for the individual and modifying at least one cheerful attribute in a virtual world experience.

18. A system, comprising:

data processing hardware; and

memory hardware in communication with the data processing hardware, the memory hardware storing instructions that when executed on the data processing hardware cause the data processing hardware to perform operations comprising;

measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual; and

modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect, comprising;

modifying a bioactive agent dosage; and

transmitting a modified bioactive agent dosage signal based on the modified bioactive agent dosage to an administration unit configured to administer the modified bioactive agent dosage to the individual.

19. A computer program product encoded on a non-transitory computer readable storage medium comprising instructions that when executed by a data processing apparatus cause the data processing apparatus to perform operations comprising:

measuring at least one effect of a combined bioactive agent and artificial sensory experience on an individual; and

modifying at least one of the bioactive agent or the artificial sensory experience at least partially based on the at least one effect, comprising;

modifying a bioactive agent dosage; and

transmitting a modified bioactive agent dosage signal based on the modified bioactive agent dosage to an administration unit configured to administer the modified bioactive agent dosage to the individual.