Methods of administering 3,4-diaminopyridine

  • US 10,793,893 B2
  • Filed: 06/29/2012
  • Issued: 10/06/2020
  • Est. Priority Date: 06/30/2011
  • Status: Active Grant
First Claim
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1. A method of treating a human patient diagnosed with a 3,4-diaminopyridine (3,4-DAP) sensitive disease in need of treatment thereof comprising administering a dose of about 2.5 mg to about 30 mg of 3,4-DAP or a pharmaceutically acceptable salt thereof to a human patient who is a slow acetylator having an N-acetyl transferase 2 (NAT2) gene comprising:

  • a C282T mutation on both alleles of the NAT2 gene;

    a T341C mutation on both alleles of the NAT2 gene;

    or a C282T mutation on one allele of the NAT2 gene and a T341C mutation on the other allele of the NAT2 gene.

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