Ribociclib tablet

  • US 10,799,506 B2
  • Filed: 04/14/2016
  • Issued: 10/13/2020
  • Est. Priority Date: 04/16/2015
  • Status: Active Grant
First Claim
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1. A coated pharmaceutical oral tablet comprising tablet core and a coating, wherein the tablet core comprises at least 40% of ribociclib succinate (w/w), the coating comprises 45.52% polyvinyl alcohol (PVA), 20% talc, 2% lecithin, and 0.48% xanthan gum, and lacks hydroxypropyl methylcellulose (HPMC), and the tablet releases at least 75% of the ribociclib or its salt after 45 minutes when tested with the rotating basket at 100 rpm with 900 ml of dissolution media pH 2 or pH 4.5, at 37°

  • C., according to United States Pharmacopeia (USP)<

    711>

    .

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