Nanodiamond particle complexes

• US 10,799,593 B2
• Filed: 07/13/2015
• Issued: 10/13/2020
• Est. Priority Date: 06/09/2008
• Status: Active Grant

• Current Assignee: Northwestern University
• Original Assignee: Northwestern University
• Inventors: Ho, Dean, Chen, Mark, Pierstorff, Erik, Robinson, Erik, Lam, Robert, Shimkunas, Rafael, Zhang, Xueqing, Huang, Houjin
• Primary Examiner(s): Bredefeld, Rachael E
• Application Number:
  US14/797,722
• Publication Number:
  US 20160058887A1
• Time in Patent Office: 1,919 Days
• Field of Search: None
• CPC Class Codes: A61K 31/704 attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin digitoxin A61K31/7048
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/6921 the form being a particulate, a powder, an adsorbate, a bead or a sphere
• CPC Class Codes: A61K 47/6923 the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
• CPC Class Codes: A61K 47/6929 the form being a nanoparticle, e.g. an immuno-nanoparticle
• CPC Class Codes: B82Y 5/00 Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
• CPC Class Codes: C07K 17/14 Peptides being immobilised on, or in, an inorganic carrier

Abstract

The present invention provides various functionalized nanodiamond particles. In particular, the present invention provides soluble complexes of nanodiamond particles and therapeutic agents, for example insoluble therapeutics, anthracycline and/or tetracycline compounds, nucleic acids, proteins, etc. The present invention also provides materials and devices for the controlled release of therapeutics, and methods for uses thereof.

Claims

1. A composition consisting essentially of:

a) purified water;

b) a plurality of doxorubicin molecules; and

c) a plurality of nanodiamond particles suspended in said purified water, wherein said plurality doxorubicin molecules are adsorbed to at least a portion of said plurality of nanodiamond particles, and wherein each of said nanodiamond particles has a diameter of approximately 2-8 nm.