Injection device

• US 10,799,646 B2
• Filed: 06/11/2014
• Issued: 10/13/2020
• Est. Priority Date: 06/11/2013
• Status: Active Grant

• Current Assignee: Cilag Gmbh International (Johnson & Johnson)
• Original Assignee: Cilag Gmbh International (Johnson & Johnson)
• Inventors: Bitar, Ahmad, Jennings, Douglas Ivan
• Primary Examiner(s): Price, Nathan R
• Assistant Examiner(s): Doubrava, John A
• Application Number:
  US14/897,360
• Publication Number:
  US 20160106924A1
• Time in Patent Office: 2,316 Days
• CPC Class Codes: A61M 2005/2006 Having specific accessories
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/208 Release is possible only when device is pushed against the skin, e.g. using a trigger which is blocked or inactive when the device is not pushed against the skin
• CPC Class Codes: A61M 2205/581 by audible feedback
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/3157 Means providing feedback signals when administration is completed A61M5/20 takes precedence
• CPC Class Codes: A61M 5/3202 Devices for protection of the needle before use, e.g. caps A61M5/50 takes precedence; for infusion spikes A61M5/1626; protectors for sharps A61B50/3001
• CPC Class Codes: A61P 1/04 for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
• CPC Class Codes: A61P 19/02 for joint disorders, e.g. arthritis, arthrosis
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 25/04 Centrally acting analgesics, e.g. opioids
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
• CPC Class Codes: A61P 29/02 without antiinflammatory effect
• CPC Class Codes: A61P 3/10 for hyperglycaemia, e.g. antidiabetics
• CPC Class Codes: A61P 31/00 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 37/04 Immunostimulants
• CPC Class Codes: A61P 37/08 Antiallergic agents antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14
• CPC Class Codes: A61P 39/02 Antidotes
• CPC Class Codes: A61P 43/00 : Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 5/00 : Drugs for disorders of the endocrine system
• CPC Class Codes: A61P 7/02 : Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
• CPC Class Codes: A61P 7/06 : Antianaemics
• CPC Class Codes: A61P 9/00 : Drugs for disorders of the cardiovascular system
• CPC Class Codes: A61P 9/10 : for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

An injection device for delivering an injection comprises a housing having a longitudinal axis, a proximal end and a distal end, the housing being arranged such that the injection is delivered from its distal end; and a release mechanism comprising an impediment, the release mechanism being moveable between a first position, in which the impediment is in an impeding position so as to impede the delivery of the injection, and a second position, in which the impediment is in a non-impeding position so as to not impede the delivery of the injection, wherein the force required to move the release mechanism from the first position to the second position varies with the distance moved by the release mechanism, the variation in the force required with distance being represented by a force profile, which is non-linear.

Claims

1. An injection device for delivering an injection comprising:

a housing having a longitudinal axis, a proximal end and a distal end, the housing being arranged such that the injection is delivered from its distal end;

an activation mechanism adapted to commence the injection, the activation mechanism comprising a trigger configured to be moveable into an active position so as to effect the delivery of the injection; and

a release mechanism comprising an impediment that interacts with the trigger, the release mechanism being moveable between a first position, in which the impediment is in an impeding position so as to impede movement of the trigger to the active position, and a second position, in which the impediment is in a non-impeding position so as to not impede movement of the trigger to the active position, wherein the force required to move the release mechanism from the first position to the second position varies with the distance moved by the release mechanism, the variation in the force required with distance being represented by a force profile, which is non-linear.

2. An injection device according to claim 1, wherein the release mechanism is resiliently biased towards the first position.

3. An injection device according to claim 1, wherein the force profile exhibits an increasing force when the release mechanism is moved from the first position to the second position.

4. An injection device according to claim 1, wherein the activation mechanism comprises a drive to provide the force required to deliver the injection.

5. An injection device according to claim 1, wherein the injection device is configured to receive a syringe.

6. An injection device according to claim 2, wherein the release mechanism comprises a moveable sleeve, the sleeve protruding from the distal end of the housing and moving proximally along the longitudinal axis of the housing when moving the release mechanism from the first position to the second position.

7. An injection device according to claim 3, wherein the rate of increase in the force first increases and then decreases when the release mechanism is moved from the first position to the second position.

8. An injection kit comprising an injection device according to claim 5;

and a syringe.

9. An injection device according to claim 6, wherein the moveable sleeve protrudes from the distal end when in the first position and is flush with the housing when in the second position.

10. An injection device according to claim 6, wherein the moveable sleeve comprises a resilient arm and the housing further comprises a camming surface inside the housing, the resilient arm being configured to ride along the camming surface as the moveable sleeve moves from the first position to the second position, the camming surface being configured such that the deformation of the resilient arm increases when the sleeve moves from the first position to the second position providing the resilient bias towards the first position.

11. An injection device according to claim 10, wherein the camming surface is generally inclined towards the longitudinal axis of the housing.

12. An injection device according to claim 10, wherein the camming surface is generally circumferentially inclined along the inner surface of the housing.

13. An injection device according to claim 10, wherein the camming surface has an undulation to provide the non-linear force profile.

15. A method of operating an injection device of any of claims 1, 14, 7, or 4-5 comprising the steps of moving the release mechanism from the first position towards the second position;

and

delivering the injection after detecting the non-linear nature of the force profile.

16. An injection device according to any one of claims 1, 14, 7, or 4-5 or an injection kit according to claim 8 containing a substance selected from the group consisting of:

golimumab, hormones, antitoxins, substances for the control of pain, substances for the control of thrombosis, substances for the control or elimination of infection, peptides, proteins, human insulin or a human insulin analogue or derivative, polysaccharide, DNA, RNA, enzymes, antibodies, oligonucleotide, antiallergics, antihistamines, anti-inflammatories, corticosteroids, disease modifying anti-rheumatic drugs, erythropoietin, or vaccines, for use in the treatment or prevention of rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, hormone deficiency, toxicity, pain, thrombosis, infection, diabetes mellitus, diabetic retinopathy, acute coronary syndrome, angina, myocardial infarction, atherosclerosis, cancer, macular degeneration, allergy, hay fever, inflammation, anaemia, or myelodysplasia, or in the expression of protective immunity.

17. An injection device for use in the treatment or prevention rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, ulcerative colitis, hormone deficiency, toxicity, pain, thrombosis, infection, diabetes mellitus, diabetic retinopathy, acute coronary syndrome, angina, myocardial infarction, atherosclerosis, cancer, macular degeneration, allergy, hay fever, inflammation, anaemia, or myelodysplasia, or in the expression of protective immunity, by delivery of a substance selected from the group consisting of:

golimumab, hormones, antitoxins, substances for the control of pain, substances for the control of thrombosis, substances for the control or elimination of infection, peptides, proteins, human insulin or a human insulin analogue or derivative, polysaccharide, DNA, RNA, enzymes, antibodies, oligonucleotide, antiallergics, antihistamines, anti-inflammatories, corticosteroids, disease modifying anti-rheumatic drugs, erythropoietin, or vaccines, to a human subject by using the injection device, wherein the injection device is an injection device according to any one of claims 1, 14, 7, or 4-5 or an injection kit according to claim 8.

14. An injection device for delivering an injection comprising:

a housing having a longitudinal axis, a proximal end and a distal end, the housing being arranged such that the injection is delivered from its distal end;

an activation mechanism adapted to commence the injection, the activation mechanism comprising a trigger configured to be moveable into an active position so as to effect the delivery of the injection; and

a release mechanism comprising an impediment that interacts with the trigger, the release mechanism being moveable between a first position, in which the impediment is in an impeding position so as to impede movement of the trigger to the active position, and a second position, in which the impediment is in a non-impeding position so as to not impede movement of the trigger to the active position, wherein the injection device produces an audible signal when the release mechanism is moved from the first position to the second position, wherein the force required to move the release mechanism from the first position to the second position varies with the distance moved by the release mechanism, the variation in the force required with distance being represented by a force profile, which is non-linear.