Systems and method for deep brain stimulation therapy
First Claim
1. A method for performing deep brain stimulation (DBS) therapy, the method comprising:
- pre-operatively acquiring at least one pre-operative image of a brain of a patient with at least one imaging sub-system;
determining a location of a Nucleus Basalis of Meynert (NBM) for therapy in the at least one pre-operative image;
intra-operatively acquiring at least one intra-operative image of the brain after obtaining an access opening through a skull of the patient and after positioning a fiducial on or within the brain through the access opening;
performing surgical planning based on the at least one pre-operative image and the at least one intra-operative image;
advancing a first lead having a first plurality of deep brain stimulation (DBS) electrodes to a first target position proximate to or within a first NBM area;
advancing a second lead having a second plurality of DBS electrodes to a second target position proximate to or within a second NBM area;
coupling the first and second leads to an implantable pulse generator (IPG) configured to deliver DBS pulses through the respective pluralities of DBS electrodes to the first and second NBM areas, the IPG to deliver DBS pulses for treating symptoms associated with Alzheimer'"'"'s Disease (AD); and
delivering an NBM therapy utilizing a first subset of the first plurality of DBS electrodes to stimulate the first NBM area and delivering a Nucleus Accumbens (NAcc) therapy utilizing a second subset of the first plurality of DBS electrodes to stimulate an NAcc area proximate to the first NBM area, the first and second subsets of the first plurality of DBS electrodes having at least one different electrode.
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Abstract
A system and method for performing deep brain stimulation (DBS) therapy are provided. The method and system include pre-operatively acquiring at least one pre-operative image of the brain with at least one imaging sub-system and determining a location of a Nucleus Basalls of Meynert (NBM) for therapy in the at least one pre-operative image, and intra-operatively acquiring at least one intra-operative image of the brain after obtaining an access opening through the skull. The method and system further provide performing surgical planning based on the pre-operative image in the intra-operative image, advancing a lead having DBS electrodes on the lead to a target position proximate to or within the NBM area, and coupling the lead to an implantable pulse generator (IPG) configured to deliver DBS pulses through the DBS electrodes to the NBM. Further, the IPG is configured to deliver DBS pulses for treating symptoms associated with Alzheimer'"'"'s disease.
29 Citations
16 Claims
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1. A method for performing deep brain stimulation (DBS) therapy, the method comprising:
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pre-operatively acquiring at least one pre-operative image of a brain of a patient with at least one imaging sub-system; determining a location of a Nucleus Basalis of Meynert (NBM) for therapy in the at least one pre-operative image; intra-operatively acquiring at least one intra-operative image of the brain after obtaining an access opening through a skull of the patient and after positioning a fiducial on or within the brain through the access opening; performing surgical planning based on the at least one pre-operative image and the at least one intra-operative image; advancing a first lead having a first plurality of deep brain stimulation (DBS) electrodes to a first target position proximate to or within a first NBM area; advancing a second lead having a second plurality of DBS electrodes to a second target position proximate to or within a second NBM area; coupling the first and second leads to an implantable pulse generator (IPG) configured to deliver DBS pulses through the respective pluralities of DBS electrodes to the first and second NBM areas, the IPG to deliver DBS pulses for treating symptoms associated with Alzheimer'"'"'s Disease (AD); and delivering an NBM therapy utilizing a first subset of the first plurality of DBS electrodes to stimulate the first NBM area and delivering a Nucleus Accumbens (NAcc) therapy utilizing a second subset of the first plurality of DBS electrodes to stimulate an NAcc area proximate to the first NBM area, the first and second subsets of the first plurality of DBS electrodes having at least one different electrode. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system for performing deep brain stimulation (DBS) therapy, the system comprising:
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a surgical planning (SP) work station having an input configured to receive at least one pre-operative image of a brain of a patient with at least one imaging sub-system; the SP work station configured to permit a user to determine a location of a Nucleus Basalis of Meynert (NBM) for therapy in the at least one pre-operative image; the SP work station having an input configured to receive at least one intra-operative image of the brain after obtaining an access opening through a skull of the patient and after positioning a fiducial on or within the brain through the access opening; the SP work station configured to perform surgical planning based on the at least one pre-operative image and the at least one intra-operative image; a first lead having a first plurality of deep brain stimulation (DBS) electrodes, the first lead configured to be advanced to a first target position proximate to or within a first NBM area; a second lead having a second plurality of DBS electrodes, the second lead configured to be advanced to a second target position proximate to or within a second NBM area; an implantable pulse generator (IPG) coupled to the first and second leads, the IPG configured to deliver DBS pulses through the respective pluralities of DBS electrodes to the first and second NBM areas, the IPG configured to deliver DBS pulses for treating symptoms associated with Alzheimer'"'"'s Disease (AD); and the IPG further configured to deliver an NBM therapy utilizing a first subset of the first plurality of DBS electrodes to stimulate the first NBM area and to deliver a Nucleus Accumbens (NAcc) therapy utilizing a second subset of the first plurality of DBS electrodes to stimulate an NAcc area proximate to the first NBM area, the first and second subsets of the first plurality of DBS electrodes having at least one different electrode. - View Dependent Claims (11, 12, 13, 14, 15, 16)
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Specification