Implantable therapeutic device
First Claim
1. An ophthalmic drug delivery device for extended release of one or more therapeutic agents into an eye, the device comprising:
- an inlet port positioned within a retention structure near a proximal end region of the device;
a penetrable element coupled to and extending within at least a portion of the inlet port;
a rigid, porous drug release structure comprising sintered material and positioned within an outlet of the device and having a first surface and a second opposite surface, the rigid porous structure further comprising a plurality of interconnecting, irregularly shaped channels; and
an expandable reservoir formed of a flexible, non-permeable barrier material and having a reservoir volume configured to contain the one or more therapeutic agents, the reservoir configured to enlarge from a first narrow profile configuration to an expanded profile configuration upon filling with the one or more therapeutic agents,wherein the porous drug release structure is positioned at a distal end of the device and distal to the reservoir volume, and the first surface of the porous drug release structure is exposed to the reservoir volume and the second surface of the porous drug release structure is exposed to the vitreous of the eye such that the reservoir is in fluid communication with the outlet through the porous drug release structure.
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Accused Products
Abstract
A therapeutic device to release a therapeutic agent comprises a porous structure coupled to a container comprising a reservoir. The reservoir comprises a volume sized to release therapeutic amounts of the therapeutic agent for an extended time when coupled to the porous structure and implanted in the patient. The porous structure may comprise a first side coupled to the reservoir and a second side to couple to the patient to release the therapeutic agent. The length of the channels extending from the first side to the second side may comprise an effective length greater than a distance across the porous structure from the first side to the second side. The therapeutic device may comprise a penetrable barrier to inject therapeutic agent into the device when implanted in the patient.
452 Citations
19 Claims
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1. An ophthalmic drug delivery device for extended release of one or more therapeutic agents into an eye, the device comprising:
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an inlet port positioned within a retention structure near a proximal end region of the device; a penetrable element coupled to and extending within at least a portion of the inlet port; a rigid, porous drug release structure comprising sintered material and positioned within an outlet of the device and having a first surface and a second opposite surface, the rigid porous structure further comprising a plurality of interconnecting, irregularly shaped channels; and an expandable reservoir formed of a flexible, non-permeable barrier material and having a reservoir volume configured to contain the one or more therapeutic agents, the reservoir configured to enlarge from a first narrow profile configuration to an expanded profile configuration upon filling with the one or more therapeutic agents, wherein the porous drug release structure is positioned at a distal end of the device and distal to the reservoir volume, and the first surface of the porous drug release structure is exposed to the reservoir volume and the second surface of the porous drug release structure is exposed to the vitreous of the eye such that the reservoir is in fluid communication with the outlet through the porous drug release structure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification