Apparatuses and methods for neuromodulation

• US 10,814,131 B2
• Filed: 09/13/2016
• Issued: 10/27/2020
• Est. Priority Date: 11/26/2012
• Status: Active Grant

• Current Assignee: Thync Global, Inc.
• Original Assignee: Thync Global, Inc.
• Inventors: Goldwasser, Isy, Tyler, William J., Charlesworth, Jonathan, Pal, Sumon K., Wetmore, Daniel Z., Jeffery, Douglas, Law, Wing, Egnal, Jason, Thakur, Anil, Demers, Remi, Hamlin, Jay Frederick, Piersiak, Rafal
• Primary Examiner(s): Porter, Allen
• Application Number:
  US15/264,224
• Publication Number:
  US 20170224990A1
• Time in Patent Office: 1,505 Days
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0476 Array electrodes (including any electrode arrangement with more than one electrode for at least one of the polarities)
• CPC Class Codes: A61N 1/0492 Patch electrodes A61N1/0412, A61N1/0428 take precedence
• CPC Class Codes: A61N 1/36014 External stimulators, e.g. with patch electrodes external pacemakers A61N1/3625
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition

Abstract

Apparatuses (e.g., devices, systems), and methods for transdermal electrical stimulation (TES). Apparatuses described herein can be self-contained, lightweight, and wearable. The apparatuses and methods described herein be configured to apply an ensemble current waveform between the two or more electrodes, wherein the ensemble current waveform comprises a series of component waveforms that are sequentially applied, and wherein each component waveform is different from a component waveform immediately before it and wherein transitions between the component waveforms temporally correlates with transitions in the sensory experience. Also described are neurostimulators for application of transdermal electrical stimulation (TES) and methods of using them for comfortably inducing a cognitive effect. Also described are Methods and apparatuses for amplitude modulation of all or a portion of an ensemble waveform to modify a user'"'"'s cognitive state by transdermal electrical stimulation (TES).

Claims

1. A transdermal electrical stimulation (TES) device, the device comprising:

a housing having a first surface;

a first connector and a second connector, wherein the first connector is configured to electrically connect with a first electrode and the second connector is configured to electrically connect with a second electrode; and

a TES controller at least partially within the housing, the controller comprising;

a waveform generator configured to deliver a pulsed, asymmetric, biphasic electrical stimulation signal between the first and second connectors, and

a capacitive discharge circuit triggered by the controller and connected to one or both of the first and second connectors and configured to deliver a capacitive discharging pulse between a positive pulse and a negative pulse of the biphasic electrical stimulation signal to discharge a capacitive charge on either or both the first electrode and the second electrode.

2. The device of claim 1, wherein the capacitive discharge circuit includes a double H-Bridge circuit configured to generate the capacitive discharging pulse.

3. The device of claim 1, wherein the first connector and a second connector are on the first surface.

4. The device of claim 1, wherein the controller is configured to trigger the capacitive discharge circuit multiple times within each cycle of the pulsed, asymmetric, biphasic electrical stimulation signal.

5. The device of claim 1, wherein the capacitive discharge circuit is configured to generate the capacitive discharging pulse so that it lasts between about 1 microsecond and 1 millisecond (ms).

6. The device of claim 1, further comprising a wireless communication module within the housing and connected to the controller.

7. The device of claim 1, further comprising a first electrode connected to the first connector and a second electrode connected to the second connector.

8. The device of claim 1, further wherein the controller is configured to trigger the capacitive discharge circuit to deliver the capacitive discharging pulse at a start or an end of a positive-going portion of the biphasic electrical signal.

9. The device of claim 1, further wherein the controller is configured to activate the capacitive discharge circuit to deliver the capacitive discharging pulse at a start or an end of a negative-going portion of the biphasic electrical signal.

10. The device of claim 1, wherein the controller includes a switch configured to turn off the current source for delivering the electrical stimulation signal when the capacitive discharge circuit is triggered.

11. The device of claim 1, wherein the controller is configured to trigger the capacitive discharging pulse after the positive pulse or the negative pulse.

12. A transdermal electrical stimulation (TES) device, the device comprising:

a housing;

a first surface on the housing;

a first connector and a second connector on the first surface and separated by between 0.5 inches and 1.5 inches, wherein the first connector is configured to electrically connect with a first electrode of an electrode apparatus and the second connector is configured to electrically connect with a second electrode; and

a TES controller at least partially within the housing, the controller comprising;

a waveform generator configured to deliver a pulsed, asymmetric, biphasic electrical stimulation signal between the first and second connectors, and

a capacitive discharge circuit triggered by the controller and connected to one or both of the first and second connectors and configured to deliver a gradual capacitive discharging pulse between a positive pulse and a negative pulse of the biphasic electrical stimulation signal, the capacitive discharging pulse delivering either or both;

a first charge to counter a first capacitive charge on the first electrode, and a second charge to counter a second capacitive charge on the second electrode.

13. A method of applying transdermal electrical stimulation to a back of a subject'"'"'s neck with a transdermal electrical stimulation (TES) device, the method comprising:

delivering a pulsed, asymmetric, biphasic electrical stimulation signal between a pair of electrodes of a TES device attached to the back of the subject'"'"'s neck, wherein the TES device comprises a first connector configured to electrically connect with a first electrode of the pair of electrodes and a second connector configured to electrically connect with a second electrode of the pair of electrodes, and a housing at least partially enclosing a controller having a waveform generator and a capacitive discharge circuit; and

applying a capacitive discharging pulse between a positive pulse and a negative pulse of the biphasic electrical stimulation signal, the capacitive discharging pulse delivering either or both;

a first charge that counters a first capacitive charge on the first electrode, and a second charge that counters a second capacitive charge on the second electrode.

14. The method of claim 13, wherein the capacitive discharging pulse is triggered after the positive pulse or the negative pulse.

15. A transdermal electrical stimulation (TES) device, the device comprising:

a housing having a first surface;

a first electrode and a second electrode; and

a TES controller at least partially within the housing, the controller comprising;

a waveform generator configured to deliver a pulsed, asymmetric, biphasic electrical stimulation signal between the first and second electrodes, the biphasic pulse including a positive pulse and a negative pulse, and

a capacitive discharge circuit triggered by the controller and connected to one or both of the first and second electrodes and configured to deliver a capacitive discharging pulse that begins at a falling edge of the positive pulse or a rising edge of the negative pulse of the biphasic electrical stimulation signal to discharge a capacitive charge on either or both of the first electrode and the second electrode.