Movement disorder symptom control
First Claim
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1. A method comprising:
- acquiring, with a medical device, a plurality of electrical signals from a brain of a patient being treated for a movement disorder with a medication and electrical stimulation, wherein at least one electrical signal of the plurality of electrical signals is acquired from a motor cortex of the brain and at least one electrical signal of the plurality of electrical signals is acquired from a subthalamic nucleus (STN) of the brain;
determining whether at least a first predetermined biomarker is present in a first set of electrical signals of the plurality of electrical signals, the first predetermined biomarker associated with at least one of the patient being over-treated or the presence of side effects of the medication;
determining whether at least a second predetermined biomarker is present in a second set of electrical signals of the plurality of electrical signals, the second predetermined biomarker associated with at least one of the patient being under-treated or the presence of movement disorder symptoms, the second set of electrical signals comprising the at least one electrical signal acquired from the STN, the second predetermined biomarker comprises a low beta band peak in the at least one electrical signal acquired from the STN, wherein the first set of electrical signals is not identical to the second set of electrical signals; and
titrating, based on whether or not the first predetermined biomarker is present and whether or not the second predetermined biomarker is present, at least one therapy parameter of the electrical stimulation to maintain the patient within a therapeutic window in which movement disorder symptoms and side effects of the medication are reduced.
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Abstract
The disclosure describes a method and system or controlling symptoms of patients suffering from Parkinson'"'"'s Disease. In some examples, one or more biomarkers indicative of a patient'"'"'s present symptoms are determined. The biomarkers may be used to control therapy delivered to the patient in a closed-loop manner. In addition, biomarkers may be used as an indication of therapy effectiveness.
40 Citations
21 Claims
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1. A method comprising:
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acquiring, with a medical device, a plurality of electrical signals from a brain of a patient being treated for a movement disorder with a medication and electrical stimulation, wherein at least one electrical signal of the plurality of electrical signals is acquired from a motor cortex of the brain and at least one electrical signal of the plurality of electrical signals is acquired from a subthalamic nucleus (STN) of the brain; determining whether at least a first predetermined biomarker is present in a first set of electrical signals of the plurality of electrical signals, the first predetermined biomarker associated with at least one of the patient being over-treated or the presence of side effects of the medication; determining whether at least a second predetermined biomarker is present in a second set of electrical signals of the plurality of electrical signals, the second predetermined biomarker associated with at least one of the patient being under-treated or the presence of movement disorder symptoms, the second set of electrical signals comprising the at least one electrical signal acquired from the STN, the second predetermined biomarker comprises a low beta band peak in the at least one electrical signal acquired from the STN, wherein the first set of electrical signals is not identical to the second set of electrical signals; and titrating, based on whether or not the first predetermined biomarker is present and whether or not the second predetermined biomarker is present, at least one therapy parameter of the electrical stimulation to maintain the patient within a therapeutic window in which movement disorder symptoms and side effects of the medication are reduced. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A system comprising:
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an implantable medical device comprising a memory and a processor; and a plurality of electrodes in communication with the implantable medical device, the plurality of electrodes configured to be implanted in a brain of a patient being treated for a movement disorder with a medication and electrical stimulation; wherein the processor is configured to; acquire, via the plurality of electrodes, a plurality of electrical signals, wherein at least one electrical signal of the plurality of electrical signals is acquired from a motor cortex of the brain and at least one electrical signal of the plurality of electrical signals is acquired from a subthalamic nucleus (STN) of the brain; determine whether at least a first predetermined biomarker is present in a first set of electrical signals of the plurality of electrical signals, the first predetermined biomarker associated with at least one of the patient being over-treated or the presence of side effects of the medication; determine whether at least a second predetermined biomarker is present a second set of electrical signals of the plurality of electrical signals, the second predetermined biomarker associated with at least one of the patient being under-treated or the presence of movement disorder symptoms, the second set of electrical signals comprising the at least one electrical signal acquired from the STN, the second predetermined biomarker comprises a low beta band peak in the at least one electrical signal acquired from the STN, wherein the first set of electrical signals is not identical to the second set of electrical signals; and titrate, based on whether or not the first predetermined biomarker is present and whether or not the second predetermined biomarker is present, at least one therapy parameter of the electrical stimulation to maintain the patient within a therapeutic window in which movement disorder symptoms and side effects of the medication are reduced. - View Dependent Claims (13, 14, 15, 16, 17, 18, 19, 20)
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21. A system comprising:
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means for acquiring, with a medical device, a plurality of electrical signals from a brain of a patient being treated for a movement disorder with a medication and electrical stimulation, wherein at least one electrical signal of the plurality of electrical signals is acquired from a motor cortex of the brain and at least one electrical signal of the plurality of electrical signals is acquired from a subthalamic nucleus (STN) of the brain; means for determining whether at least a first predetermined biomarker is present in a first set of electrical signals of the plurality of electrical signals, the first predetermined biomarker associated with at least one of the patient being over-treated or the presence of side effects of the medication; means for determining whether at least a second predetermined biomarker is present in a second set of electrical signals of the plurality of electrical signals, the second predetermined biomarker associated with at least one of the patient being under-treated or the presence of movement disorder symptoms, the second set of electrical signals comprising the at least one electrical signal acquired from the STN, the second predetermined biomarker comprises a low beta band peak in the at least one electrical signal acquired from the STN, wherein the first set of electrical signals is not identical to the second set of electrical signals; and means for titrating, based on whether or not the first predetermined biomarker is present and whether or not the second predetermined biomarker is present, at least one therapy parameter of the electrical stimulation to maintain the patient within a therapeutic window in which movement disorder symptoms and side effects of the medication are reduced.
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Specification