Continuous assessment of biological analytes for general wellness

• US 10,820,845 B2
• Filed: 09/05/2017
• Issued: 11/03/2020
• Est. Priority Date: 09/03/2016
• Status: Active Grant

• Current Assignee: Biorasis Incorporated
• Original Assignee: Biorasis Incorporated
• Inventors: Papadimitrakopoulos, Fotios, Costa, Antonio, Jain, Faquir C., Kastellorizios, Michael
• Primary Examiner(s): Tran, Dzung
• Application Number:
  US15/695,479
• Publication Number:
  US 20180064382A1
• Time in Patent Office: 1,155 Days
• CPC Class Codes: A61B 2560/0219 of externally powered implanted units
• CPC Class Codes: A61B 2560/0271 using a remote monitoring unit
• CPC Class Codes: A61B 2562/08 Sensors provided with means for identification, e.g. barcodes or memory chips
• CPC Class Codes: A61B 5/0022 Monitoring a patient using a global network, e.g. telephone networks, internet
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14542 for measuring blood gases A61B5/14551 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/15003 for venous or arterial blood
• CPC Class Codes: A61B 5/150786 Optical identification systems, e.g. bar codes, colour codes
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61B 5/7246 using correlation, e.g. template matching or determination of similarity
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16H 40/67 for remote operation

Abstract

An analyte monitoring platform consisting of a proximity communicator and an implantable biosensor that includes system architecture for biosensor authentication, identification and methods to use analyte sensors for general wellness. The system architecture also permits multi-analyte sensing. In addition, the system and methods can be used for a single analyte or combination of analytes.

Claims

1. A biosensor platform comprising:

A watch-like, proximity communicator that further comprises of a microprocessor, optical sources, photodetectors, optical circuitry, signal processors, and data communication modules;

An implantable biosensor, further comprising of sensor(s), sensor interface circuit(s), signal processor(s), electronic multiplexer(s), photovoltaics(s), optoelectronic transmitters and receivers, and nonvolatile memory;

wherein the photovoltaics are interfaced with a voltage regulator to provide a stable power to the electrical components and circuits in the implantable biosensor,

wherein the biosensor receives from the optical transmitter located on the proximity communicator coded optical pulses and using at least one photodetector operating at an operable wavelength that converts these optical pulses into electrical pulses,

wherein the electrical pulses are decoded by a code detect unit,

wherein the code authentication data is transmitted by the optical transmitter to the photodetector receiver in the proximity communicator,

wherein the implantable biosensor includes analyte sensors, protein sensors, and physiologic sensors, such that the sensors are connected to electronic circuitry, signal processing unit(s) and multiplexer(s),

wherein the analyte sensor data is fed to an optical driving circuit a that converts electrical pulses into optical pulses and is transmitted by an optical transmitter to the associated photodetector of the proximity communicator.

2. The implantable biosensor of claim 1, wherein the coded pulses enables the operation of transmitting analyte biosensing data from non-volatile memory to the associated proximity communicator.

3. The implantable biosensor of claim 1, wherein the coded pulses are for biosensor platform to the proximity communication authentication and comprise of a 2 to 256-bit authentication code.

4. The implantable biosensor of claim 1, wherein the coded pulses are for biosensor platform to the proximity communication identification and comprise of a 2 to 256-bit identification code.

5. The implantable biosensor of claim 1, comprising of multiple code detect units.

6. The implantable biosensor of claim 1, comprising of a mode select unit.

7. The proximity communicator of claim 1, comprising of an interface for a smartphone, computer or cloud-based service.

8. The biosensing platform of claim 1, comprising of a computer processing algorithm that stores and/or transmits normal analyte concentrations at or within the normal analyte range, wherein the computer processing algorithm does not store and/or transmit analyte concentrations outside of the normal analyte range, wherein the biosensing platform is intended only for general wellness use.

9. The biosensing platform of claim 1, where its membranes are designed to limit the diffusion of the analyte to reach the sensing platform, and that the maximum analyte concentration is less than the highest value in the normal analyte concentration range.

10. The biosensing platform of claim 1, comprising of an optical, electromagnetic radiation source, wherein the optical source power is regulated to prevent the detection of analyte levels lower than the lowest value in the normal analyte concentration range.

11. The biosensing platform of claim 1, comprising of an optical, electromagnetic radiation source, wherein the source power is regulated to prevent the detection of analyte levels higher than the highest value in the normal analyte concentration range.

12. The biosensing platform of claim 1, comprising of an electromagnetic radiation detector, wherein the detector is regulated to prevent the detection of analyte levels higher than the highest value in the normal analyte concentration range.

13. The biosensing platform of claim 1, comprising of an electromagnetic radiation detector, wherein the detector is regulated to prevent the detection of analyte levels lower than the lowest value in the normal analyte concentration range.