Detecting and correcting for changes to an analyte indicator
First Claim
1. An analyte sensor for measurement of an analyte in a medium within a living animal, the analyte sensor comprising:
- an analyte indicator configured to exhibit a first detectable property that varies in accordance with (i) an amount or concentration of the analyte in the medium and (ii) an extent to which the analyte indicator has degraded;
a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded, wherein the extent to which the degradation indicator has degraded corresponds to the extent to which the analyte indicator has degraded; and
sensor elements configured to generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator;
wherein the degradation indicator is a compound of formula I;
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Accused Products
Abstract
A sensor, system, and method for detecting and correcting for changes to an analyte indicator of an analyte sensor. The analyte indicator may be configured to exhibit a first detectable property that varies in accordance with an analyte concentration and an extent to which the analyte indicator has degraded. The analyte sensor may also include a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded. The analyte sensor may generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator. The analyte sensor may be part of a system that also includes a transceiver. The transceiver may use the analyte and degradation measurements to calculate an analyte level.
20 Citations
22 Claims
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1. An analyte sensor for measurement of an analyte in a medium within a living animal, the analyte sensor comprising:
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an analyte indicator configured to exhibit a first detectable property that varies in accordance with (i) an amount or concentration of the analyte in the medium and (ii) an extent to which the analyte indicator has degraded; a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded, wherein the extent to which the degradation indicator has degraded corresponds to the extent to which the analyte indicator has degraded; and sensor elements configured to generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator; wherein the degradation indicator is a compound of formula I; - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12)
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13. An analyte sensor for measurement of an analyte in a medium within a living animal, the analyte sensor comprising:
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an analyte indicator configured to exhibit a first detectable property that varies in accordance with (i) an amount or concentration of the analyte in the medium and (ii) an extent to which the analyte indicator has degraded; a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded, wherein the extent to which the degradation indicator has degraded corresponds to the extent to which the analyte indicator has degraded; and sensor elements configured to generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator; wherein the degradation indicator comprises a molecule selected from the group consisting of; - View Dependent Claims (14)
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15. A method comprising:
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using an analyte indicator of an analyte sensor to measure an amount or concentration of an analyte in a medium; using a degradation indicator of the analyte sensor to measure an extent to which the degradation indicator has degraded; using a sensor interface device of a transceiver to receive from the analyte sensor an analyte measurement indicative of the amount or concentration of the analyte in the medium; using the sensor interface device of the transceiver to receive from the analyte sensor a degradation measurement indicative of the extent to which the degradation indicator has degraded; using a controller of the transceiver to calculate an extent to which the analyte indicator of the analyte sensor has degraded based at least on the received degradation measurement; using the controller of the transceiver to adjust a conversion function based on the calculated extent to which the analyte indicator has degraded; using the controller of the transceiver to calculate an analyte level using the adjusted conversion function and the received analyte measurement; and displaying the calculated analyte level; wherein the degradation indicator is a compound of formula I;
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16. A method comprising:
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using an analyte indicator of an analyte sensor to measure an amount or concentration of an analyte in a medium; using a degradation indicator of the analyte sensor to measure an extent to which the degradation indicator has degraded; using a sensor interface device of a transceiver to receive from the analyte sensor an analyte measurement indicative of the amount or concentration of the analyte in the medium; using the sensor interface device of the transceiver to receive from the analyte sensor a degradation measurement indicative of the extent to which the degradation indicator has degraded; using a controller of the transceiver to calculate an extent to which the analyte indicator of the analyte sensor has degraded based at least on the received degradation measurement; using the controller of the transceiver to adjust a conversion function based on the calculated extent to which the analyte indicator has degraded; using the controller of the transceiver to calculate an analyte level using the adjusted conversion function and the received analyte measurement; and displaying the calculated analyte level; wherein the degradation indicator comprises a molecule selected from the group consisting of; - View Dependent Claims (17)
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18. An analyte monitoring system comprising:
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an analyte sensor including; an analyte indicator configured to exhibit a first detectable property that varies in accordance with (i) an amount or concentration of an analyte in a medium and (ii) an extent to which the analyte indicator has degraded; a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded; sensor elements configured to generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator; and a transceiver interface device; and a transceiver including; a sensor interface device; and a controller configured to; (i) receive the analyte measurement from the analyte sensor via the transceiver interface device of the analyte sensor and the sensor interface device; (ii) receive the degradation measurement from the analyte sensor via the transceiver interface device of the analyte sensor and the sensor interface device; (iii) calculate an extent to which the analyte indicator of the analyte sensor has degraded based at least on the received degradation measurement; (iv) adjust a conversion function based on the calculated extent to which the analyte indicator has degraded; (v) calculate an analyte level using the adjusted conversion function and the received analyte measurement; wherein the degradation indicator is a compound of formula I; - View Dependent Claims (19, 20)
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21. An analyte monitoring system comprising:
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an analyte sensor including; an analyte indicator configured to exhibit a first detectable property that varies in accordance with (i) an amount or concentration of an analyte in a medium and (ii) an extent to which the analyte indicator has degraded; a degradation indicator configured to exhibit a second detectable property that varies in accordance with an extent to which the degradation indicator has degraded; sensor elements configured to generate (i) an analyte measurement based on the first detectable property exhibited by the analyte indicator and (ii) a degradation measurement based on the second detectable property exhibited by the degradation indicator; and a transceiver interface device; and a transceiver including; a sensor interface device; and a controller configured to; (i) receive the analyte measurement from the analyte sensor via the transceiver interface device of the analyte sensor and the sensor interface device; (ii) receive the degradation measurement from the analyte sensor via the transceiver interface device of the analyte sensor and the sensor interface device; (iii) calculate an extent to which the analyte indicator of the analyte sensor has degraded based at least on the received degradation measurement; (iv) adjust a conversion function based on the calculated extent to which the analyte indicator has degraded; (v) calculate an analyte level using the adjusted conversion function and the received analyte measurement wherein the degradation indicator comprises a molecule selected from the group consisting of; - View Dependent Claims (22)
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Specification