Acoustic sensor and ventilation monitoring system

• US 10,842,416 B2
• Filed: 08/22/2019
• Issued: 11/24/2020
• Est. Priority Date: 08/20/2018
• Status: Active Grant

• Current Assignee: Thomas Jefferson University (Main Line Health System), RTM Vitals Signs, LLC
• Original Assignee: Thomas Jefferson University (Main Line Health System)
• Inventors: Joseph, Jeffrey I, Helmond, Noud Van, Torjman, Marc C, Devine, Denise L, Dicciani, Nance K, Loeum, Channy
• Primary Examiner(s): Cerioni, Daniel L
• Assistant Examiner(s): Dulman, Raymond P
• Application Number:
  US16/547,818
• Publication Number:
  US 20200054278A1
• Time in Patent Office: 460 Days
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/022 by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/113 occurring during breathing
• CPC Class Codes: A61B 5/1135 by monitoring thoracic expansion
• CPC Class Codes: A61B 5/33 specially adapted for cooperation with other devices
• CPC Class Codes: A61B 5/4806 Sleep evaluation A61B5/4821 takes precedence; devices for inducing sleep A61M21/02
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61B 7/003 Detecting lung or respiration noise

Abstract

A method of monitoring respiration with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method includes correlating the measured sound into a measurement of tidal volume and generating at least one from the group consisting of an alert and an alarm if the measured tidal volume falls outside of a predetermined range.

Claims

1. A method of predicting an opioid overdose with an acoustic measurement device, the acoustic measurement device having a sound transducer, the sound transducer configured to measure sound associated with airflow through a mammalian trachea, the method comprising:

correlating the measured sound into a measurement of tidal volume;

calculating an absolute tidal volume, a direction of tidal volume, and a rate of change of tidal volume;

assigning a risk index value of a likelihood of the opioid overdose to each of the absolute tidal volume, the direction of tidal volume, and the rate of change of tidal volume, each risk index value being one selected from the group consisting of a positive score and a negative score based on a predefined scale, the positive score indicating a high likelihood of an opioid overdose and the negative score indicating a low likelihood of an opioid overdose;

calculating a sum of the risk index values assigned to each of the absolute tidal volume, the direction of tidal volume, and the rate of change of tidal volume; and

generating at least one selected from the group consisting of an alert and an alarm if the calculated sum exceeds a predetermined risk score threshold.

2. The method of claim 1, wherein the measurement of sound associated with airflow through the trachea occurs periodically.

3. The method of claim 1, wherein the acoustic measurement device includes a housing, and wherein the sound transducer is suspended within the housing.

4. The method of claim 3, wherein the housing of the acoustic measurement device has a width between 0.5 cm and 2.5 cm.

5. The method of claim 3, wherein the housing defines an opening, and wherein the sound transducer is disposed on an end of the housing opposite the opening.

6. The method of claim 3, wherein the housing is configured to releasably couple to skin of the mammalian trachea.

7. The method of claim 6, wherein the housing includes a diaphragm configured to vibrate in response to sound.

8. The method of claim 7, wherein the housing is configured to engage a coupling component releasably adhered to the skin, and wherein the coupling component includes the diaphragm.

9. The method of claim 8, wherein the housing includes a connector configured to engage the coupling component.

10. The method of claim 1, wherein the acoustic measurement device further includes an accelerometer configured to measure a relative body position and a movement of the mammal, and wherein the method further includes modifying the respective predetermined range based on the mammal'"'"'s relative position and movement.

11. The method of claim 1, further including filtering out ambient noise from the measured sound.

20. The method of claim 1, further including multiplying at least one of the direction of tidal volume and the rate of change of tidal volume by a predetermined weighting value, the predetermined weighting value being automatically adjusted over a period of time.

12. A method of predicting an opioid overdose in a mammal, comprising:

continually measuring sound waves emanating from an airflow into and out of the mammalian trachea with an acoustic measurement device releasably affixable to the mammal'"'"'s skin proximate the mammalian trachea;

correlating the measured sound waves into a measurement of the mammal'"'"'s respiratory rate and tidal volume;

calculating a direction trend and rate of change of the respiratory rate and tidal volume at a predetermined interval;

during the predetermined interval, assigning a risk index value to the mammal'"'"'s;

(a) respiratory rate and tidal volume;

(b) direction trend of the respiratory rate and tidal volume; and

(c) rate of change of the respiratory rate and tidal volume, each risk index value being one selected from the group consisting of a positive score and a negative score based on a predefined scale, the positive score indicating a high likelihood of an opioid overdose and the negative score indicating a low likelihood of an opioid overdose;

summing (a), (b), and (c); and

generating at least one from the group consisting of an alert and an alarm if a sum of (a), (b), and (c) falls outside of a predetermined opioid risk range.

13. The method of claim 12, further comprising:

multiplying the assigned risk index value of at least one from the group consisting of (b) and (c) by a predetermined weighting value.

14. The method of claim 13, wherein the acoustic measurement device further includes an accelerometer, and where the method further includes:

continually measuring a mammal'"'"'s activity level, body position, and snoring level;

calculating a direction trend and rate of change of the measured activity level, body position, and snoring level at the predetermined interval;

during the predetermined interval, assigning a risk index value to the mammal'"'"'s;

(d) activity level, body position, and snoring level;

(e) direction trend of the activity level, body position, and snoring level; and

(f) rate of change of the activity level, body position, and snoring level;

summing up (a)-(f); and

generating the at least one from the group consisting of the alert and the alarm if the sum of the (a)-(f) falls outside of the predetermined opioid risk range.

15. The method of claim 14, further including adhering an acoustic measuring device to the skin of the mammal proximate the trachea.

16. The method of claim 14, wherein the acoustic measuring device is configured to be in communication with a remote controller, the remote controller being configured to carry out the recited method steps.

17. The method of claim 14, further including multiplying the assigned risk index value of at least one from the group consisting of (d), (e), and (f) by the predetermined weighting value.

18. The method of claim 14, wherein the acoustic measurement device is wireless.

19. A method of predicting an opioid overdose, comprising:

at least periodically measuring sound emanating from an airflow into and out of a mammal'"'"'s trachea and lungs with an acoustic measurement device, the acoustic measurement device including a housing including at least two sound transducers, the housing being sized and configured to be adhered to the mammal'"'"'s trachea with a coupling component, the housing defining an opening, the at least two sound transducers being disposed within the housing opposite the opening; and

wirelessly communicating the measured sound to a remote controller, the remote controller being configured to;

correlate the measured sound energy into a measurement of the mammal'"'"'s respiratory rate and tidal volume;

assign a first risk index value indicating a likelihood of the opioid overdose based on the measured respiratory rate;

assign a second risk index value indicating a likelihood of the opioid overdose based on the measured tidal volume;

calculate a rate of change of the measured respiratory rate and tidal volume at over a predetermined interval;

assign a third risk index value indicating a likelihood of the opioid overdose based on the calculated rate of change of the measured respiratory rate;

assign a fourth risk index value indicating a likelihood of the opioid overdose based on the calculated rate of change of tidal volume, the first risk index value, the second risk index value, the third risk index value, and the fourth risk index value each being one selected from the group consisting of a positive score and a negative score based on a predefined scale, the positive score indicating a high likelihood of an opioid overdose and the negative score indicating a low likelihood of an opioid overdose; and

generate at least one from the group consisting of an alert and alarm if a sum of the first risk index value, the second risk index value, the third risk index value, and the fourth risk index value, exceed a predetermined risk score threshold.