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Cancer immunotherapy by radiofrequency electrical membrane breakdown (RF-EMB)

  • US 10,849,678 B2
  • Filed: 12/05/2014
  • Issued: 12/01/2020
  • Est. Priority Date: 12/05/2013
  • Status: Active Grant
First Claim
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1. A method of ablating undesirable soft tissue in a living subject, comprising:

  • introducing at least one electrode to a position within said subject, wherein said at least one electrode is electrically connected to a controller for controlling the delivery of electric pulses to said electrode, said controller comprising an electric pulse generator;

    applying to said soft tissue an electric field of between 1,500 V/cm and 10,000 V/cm and having a frequency of between 14.2 kHz and 500 kHz, including delivering, from the electric pulse generator to the at least one electrode, at least one bi-polar electric pulse; and

    by application of the electric field, causing electrical membrane breakdown of a cell membrane of a plurality of cells of said soft tissue to cause destruction of the cell membrane, immediate spillage of intracellular components into an extracellular space, and exposure of an internal constituent part of said cell membrane to said extracellular space.

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