Compositions and methods for treating rosacea and acne

  • US 10,849,847 B2
  • Filed: 07/11/2019
  • Issued: 12/01/2020
  • Est. Priority Date: 09/08/2016
  • Status: Active Grant
First Claim
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1. A method for treating acne vulgaris in a subject in need thereof, comprising topically administering to the subject a therapeutically effective amount of a breakable foam obtained from a foamable composition once daily for at least seven consecutive days, wherein the foamable composition comprises:

  • (a) a hydrophobic vehicle comprising;

    (i) about 70% to about 90% by weight of a hydrophobic solvent comprising;

    about 35% w/w to about 65% w/w of soybean oil;

    about 16.5% w/w to about 30.7% w/w of coconut oil;

    about 3.5% w/w to about 6.5% w/w of cyclomethicone; and

    about 1% w/w to about 6% w/w of light mineral oil; and

    (ii) about 10% to about 22% by weight of a foamer complex comprising;

    about 2.5% w/w to about 4.6% w/w of cetostearyl alcohol;

    about 2% w/w to about 4% w/w of stearic acid;

    about 1.8% w/w to about 3.3% w/w of myristyl alcohol;

    about 1% w/w to about 3% w/w of hydrogenated castor oil;

    about 1% w/w to about 3% w/w of beeswax;

    about 1% w/w to about 2% w/w of stearyl alcohol; and

    about 0.5% w/w to about 1.5% w/w of behenyl alcohol;

    (iii) minocycline in an amount ranging from about 1% w/w to about 4% w/w; and

    (b) a propellant in an amount ranging from about 3% to about 25% w/w;

    wherein the subject is between 15 years old and 16 years and 11 months old, wherein the foamable composition does not comprise silicon dioxide (SiO2), and wherein the minocycline is present in plasma from the subject at a concentration of at most 1.9 ng/mL before applying the seventh day of treatment with the therapeutically effective amount of the breakable foam.

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