Method and apparatus for treating hyperarousal disorders

• US 10,850,054 B2
• Filed: 10/26/2015
• Issued: 12/01/2020
• Est. Priority Date: 10/27/2014
• Status: Active Grant

• Current Assignee: ResMed Pty Ltd. (ResMed Incorporated)
• Original Assignee: ResMed Pty Ltd. (ResMed Incorporated)
• Inventors: Martin, Dion Charles Chewe, Armitstead, Jeffrey Peter, Ramanan, Dinesh
• Primary Examiner(s): Stanis, Timothy A
• Assistant Examiner(s): Gallegos, Cana A
• Application Number:
  US15/519,667
• Publication Number:
  US 20170239433A1
• Time in Patent Office: 1,863 Days
• Field of Search: 12820418
• CPC Class Codes: A61M 16/0051 with alarm devices
• CPC Class Codes: A61M 16/0069 the speed thereof being controlled by respiratory parameters, e.g. by inhalation
• CPC Class Codes: A61M 16/026 specially adapted for predicting, e.g. for determining an information representative of a flow limitation during a ventilation cycle by using a root square technique or a regression analysis
• CPC Class Codes: A61M 16/06 Respiratory or anaesthetic masks
• CPC Class Codes: A61M 16/105 Filters A61M16/047, A61M16/22 take precedence; water traps A61M16/08
• CPC Class Codes: A61M 16/107 in the inspiratory path
• CPC Class Codes: A61M 16/125 Diluting primary gas with ambient air
• CPC Class Codes: A61M 16/16 Devices to humidify the respiration air A61M16/1045 takes precedence
• CPC Class Codes: A61M 2016/0027 pressure meter
• CPC Class Codes: A61M 2016/003 with a flowmeter
• CPC Class Codes: A61M 2016/0036 in the breathing tube and used in both inspiratory and expiratory phase
• CPC Class Codes: A61M 2021/0088 modulated by a simulated respiratory frequency
• CPC Class Codes: A61M 21/02 for inducing sleep or relaxation, e.g. by direct nerve stimulation, hypnosis, analgesia for massage A61H; electrotherapy A61N, e.g. applying alternating or intermittent electric currents for producing anaesthesia A61N1/36021
• CPC Class Codes: A61M 2202/0007 introduced into the body
• CPC Class Codes: A61M 2202/0208 Oxygen
• CPC Class Codes: A61M 2205/15 Detection of leaks
• CPC Class Codes: A61M 2205/18 with alarm
• CPC Class Codes: A61M 2205/3331 Pressure; Flow
• CPC Class Codes: A61M 2205/3365 Rotational speed
• CPC Class Codes: A61M 2205/3375 Acoustical, e.g. ultrasonic, measuring means
• CPC Class Codes: A61M 2205/3561 : local, e.g. within room or hospital
• CPC Class Codes: A61M 2205/3584 : using modem, internet or bluetooth
• CPC Class Codes: A61M 2205/42 : Reducing noise
• CPC Class Codes: A61M 2205/502 : User interfaces, e.g. screens or keyboards
• CPC Class Codes: A61M 2205/581 : by audible feedback
• CPC Class Codes: A61M 2205/583 : by visual feedback
• CPC Class Codes: A61M 2230/005 : Parameter used as control input for the apparatus
• CPC Class Codes: A61M 2230/205 : partial oxygen pressure (P-O2)
• CPC Class Codes: A61M 2230/63 : Motion, e.g. physical activity

Abstract

Methods and apparatus provide automated controls for a respiratory pressure therapy device, such as a servo-ventilator. For example, a controller of a respiratory pressure therapy device may control application of pressure support ventilation therapy to an airway of a patient. The controller may control the respiratory pressure therapy device to auto-titrate an expiratory positive airway pressure (EPAP) of a pressure support ventilation therapy so as to maintain airway patency of the patient. The EPAP may be bounded below by a floor pressure limit. The controller may control the respiratory pressure therapy device to repeatedly adjust the floor pressure limit depending on events of interest during the auto-titration of the EPAP. Such methodologies may improve treatment for patients such as those suffering from sleep disordered breathing-comorbid hyperarousal disorders.

Claims

1. A method of control of a respiratory pressure therapy device to treat sleep disordered breathing (SDB)-comorbid hyperarousal disorders in a patient, the method comprising:

controlling application of pressure support ventilation therapy to an airway of the patient by a respiratory pressure therapy device;

controlling the respiratory pressure therapy device to auto-titrate an expiratory positive airway pressure (EPAP) of the pressure support ventilation therapy so as to maintain airway patency of the patient, such that the EPAP is bounded below by a floor pressure limit; and

controlling, in the respiratory pressure therapy device, a determination of repeated adjustments to the floor pressure limit depending on events of interest during the auto-titration of the EPAP, wherein an adjustment to the floor pressure limit is dependent on a number of events of interest that occur in a predetermined interval during the auto-titration of the EPAP.

2. The method according to claim 1, wherein the adjustment to the floor pressure limit is dependent on a current value of the EPAP.

3. The method according to claim 1, wherein the adjustment to the floor pressure limit comprises incrementing the floor pressure limit if a predetermined number of events of interest occur within the predetermined interval.

4. The method according to claim 3, wherein incrementing the floor pressure limit comprises increasing the floor pressure to a current value of the EPAP.

5. The method according to claim 1, wherein the events of interest are SDB events.

6. The method according to claim 1, wherein the events of interest are increments to the EPAP as a result of the auto-titration of the EPAP.

7. The method according to claim 1, further comprising determining, in the respiratory pressure therapy device, a sleep state of the patient.

8. The method according to claim 7, wherein the auto-titrating the EPAP comprises not decreasing the EPAP while the patient is determined to be in an asleep state.

9. The method according to claim 7, wherein the pressure support ventilation therapy is applied dependent on the sleep state of the patient.

10. The method according to claim 9, wherein the respiratory pressure therapy device applies pressure support ventilation therapy when the patient is determined to be in an asleep state, and the respiratory pressure therapy device applies an acclimatisation therapy when the patient is determined to be in an awake state.

11. The method according to claim 10, wherein the acclimatisation therapy is paced breathing.

12. The method according to claim 11, wherein the paced breathing is combined with biofeedback matched to an interim breathing rate target of the paced breathing.

13. The method according to claim 12, where the biofeedback is in one or more of acoustic and visual form.

14. The method according to claim 1, further comprising applying the pressure support ventilation therapy on receiving, by the respiratory pressure therapy device, a command from the patient.

15. The method according to claim 14, wherein the command is activation of a manual control.

16. The method according to claim 14, wherein the command is a sound emitted by the patient.

17. The method according to claim 14, wherein the command is a voluntary respiratory manoeuvre by the patient.

18. A method of control of a respiratory pressure therapy device to treat sleep disordered breathing (SDB)-comorbid hyperarousal disorders in a patient, the method comprising:

controlling application of pressure support ventilation therapy to an airway of the patient by a respiratory pressure therapy device;

controlling the respiratory pressure therapy device to auto-titrate an expiratory positive airway pressure (EPAP) of the pressure support ventilation therapy so as to maintain airway patency of the patient, such that the EPAP is bounded below by a floor pressure limit; and

controlling, in the respiratory pressure therapy device, a determination of repeated adjustments to the floor pressure limit depending on events of interest during the auto-titration of the EPAP, wherein the events of interest are increments to the EPAP, and the repeated adjustment of the floor pressure limit comprises repeatedly;

forming a distribution of EPAP values at which increments to the EPAP occurred over an analysis interval, and

adjusting the floor pressure limit based on statistical analysis of the distribution.

19. The method according to claim 18, wherein the adjustment of the floor pressure limit is based on a mode of the distribution.

20. The method according to claim 18, wherein the analysis interval is a night of pressure-support ventilation therapy with auto-titrating EPAP.

21. A sleep disordered breathing (SDB)-comorbid hyperarousal treatment apparatus comprising:

a pressure generator configured to deliver a flow of air at a controllable treatment pressure above atmospheric to an airway of a patient via a patient interface over an air circuit; and

a controller configured to;

control the treatment pressure of the flow of air so as to apply pressure support ventilation therapy to the airway of the patient;

auto-titrate an expiratory positive airway pressure (EPAP) of the pressure support ventilation therapy so as to maintain airway patency of the patient, such that the EPAP is bounded below by a floor pressure limit; and

determine repeated adjustments to the floor pressure limit depending on events of interest during the auto-titration of the EPAP, wherein an adjustment to the floor pressure limit is dependent on a number of events of interest that occur in a predetermined interval during the auto-titration of the EPAP.

22. The SDB-comorbid hyperarousal treatment apparatus according to claim 21, further comprising a sensor configured to generate a signal representative of a physiological characteristic of the patient, wherein the controller is further configured to determine a sleep state of the patient from the signal.

23. The SDB-comorbid hyperarousal treatment apparatus according to claim 21, further comprising a user input device comprising a manual control.

24. The SDB-comorbid hyperarousal treatment apparatus according to claim 21, further comprising an audio sensor.

25. The SDB-comorbid hyperarousal treatment apparatus according to claim 21, further comprising a data communication interface through which the controller is configured to communicate with a local external device.

26. The SDB-comorbid hyperarousal treatment apparatus according to claim 25, wherein the controller is configured to control the local external device to provide biofeedback to the patient.

27. The SDB-comorbid hyperarousal treatment apparatus according to claim 25, wherein the controller is configured to receive an audio signal from the local external device.

28. The SDB-comorbid hyperarousal treatment apparatus according to claim 25, wherein the controller is configured to receive a signal representative of a physiological characteristic of the patient from the local external device, wherein the controller is further configured to determine a sleep state of the patient from the signal.

29. A sleep disordered breathing (SDB)-comorbid hyperarousal treatment apparatus comprising:

a pressure generator configured to deliver a flow of air at a controllable treatment pressure above atmospheric to an airway of a patient via a patient interface over an air circuit; and

a controller configured to;

control the treatment pressure of the flow of air so as to apply pressure support ventilation therapy to the airway of the patient;

auto-titrate an expiratory positive airway pressure (EPAP) of the pressure support ventilation therapy so as to maintain airway patency of the patient, such that the EPAP is bounded below by a floor pressure limit; and

determine repeated adjustments to the floor pressure limit depending on events of interest during the auto-titration of the EPAP,

wherein the events of interest are increments to the EPAP, and the repeated adjustment of the floor pressure limit comprises repeated;

formation of a distribution of EPAP values at which increments to the EPAP occurred over an analysis interval, and

adjustment of the floor pressure limit based on statistical analysis of the distribution.