Polycrystalline form of dehydrophenylahistin-like compound, and manufacturing and purification method and application thereof

  • US 10,851,086 B2
  • Filed: 07/24/2017
  • Issued: 12/01/2020
  • Est. Priority Date: 08/12/2016
  • Status: Active Grant
First Claim
Patent Images

1. A crystalline form of (3Z,6Z)-3-benzylidene-6-[(5-tert-butyl-1H-imidazol-4-yl)deuteromethylene]piperazine-2,5-dione as shown in Formula (I), wherein the crystalline form is only one crystalline form selected from the group consisting of α

  • -crystalline form, β

    -crystalline form, γ

    -crystalline form and δ

    -crystalline form, wherein,the α

    -crystalline form has at least three X-ray powder diffraction characteristic peaks at 2θ

    diffraction angle of 8.415°

    ±

    0.2°

    , 11.512°

    ±

    0.2°

    , 14.824°

    ±

    0.2°

    , 17.087°

    ±

    0.2°

    , 17.278°

    ±

    0.2°

    , 19.461°

    ±

    0.2°

    , 21.350°

    ±

    0.2°

    , 22.344°

    ±

    0.2°

    or 27.621°

    ±

    0.2°

    ;

    the β

    -crystalline form has at least three X-ray powder diffraction characteristic peaks at 2θ

    diffraction angle of 7.629°

    ±

    0.2°

    , 8.052°

    ±

    0.2°

    , 12.967°

    ±

    0.2°

    , 15.327°

    ±

    0.2°

    , 16.195°

    ±

    0.2°

    , 23.194°

    ±

    0.2°

    , 23.760°

    ±

    0.2°

    , 24.129°

    ±

    0.2°

    , 24.419°

    ±

    0.2°

    , 26.465°

    ±

    0.2°

    or 29.213°

    ±

    0.2°

    ;

    the γ

    -crystalline form has at least three X-ray powder diffraction characteristic peaks at 2θ

    diffraction angle of 8.075°

    ±

    0.2°

    , 12.986°

    ±

    0.2°

    , 16.217°

    ±

    0.2°

    , 19.709°

    ±

    0.2°

    or 24.441°

    ±

    0.2°

    ;

    the δ

    -crystalline form has at least three X-ray powder diffraction characteristic peaks at 2θ

    diffraction angle of 8.075°

    ±

    0.2°

    , 12.988°

    ±

    0.2°

    , 16.201°

    ±

    0.2°

    , 17.545°

    ±

    0.2°

    , 19.084°

    ±

    0.2°

    , 19.724°

    ±

    0.2°

    , 23.710°

    ±

    0.2°

    , 24.422°

    ±

    0.2°

    , 26.485°

    ±

    0.2°

    or 29.234°

    ±

    0.2°

    ;

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