Compositions and methods for stabilization of retinoids

• US 10,864,148 B2
• Filed: 04/08/2019
• Issued: 12/15/2020
• Est. Priority Date: 04/06/2018
• Status: Active Grant

• Current Assignee: Medik8 Limited
• Original Assignee: Pangaea Laboratories Ltd.
• Inventors: Isaacs, Daniel, Isaacs, Elliot, Murugesan, Kavitha
• Primary Examiner(s): Soroush, Ali
• Application Number:
  US16/378,427
• Publication Number:
  US 20190307662A1
• Time in Patent Office: 617 Days
• CPC Class Codes: A61K 8/06 Emulsions
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 8/31 Hydrocarbons
• CPC Class Codes: A61K 8/671 Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
• CPC Class Codes: A61K 8/738 Cyclodextrins
• CPC Class Codes: A61K 8/84 obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
• CPC Class Codes: A61K 8/88 Polyamides
• CPC Class Codes: A61K 8/9789 Magnoliopsida [dicotyledons]
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The present invention relates to a composition and method for stabilisation of compounds including retinoids using the synergistic effects of beta-carotene and sodium polyaspartate.

Claims

1. A cosmetic composition comprising:

retinaldehyde;

beta-carotene; and

sodium polyaspartate.

2. The cosmetic composition according to claim 1, wherein the beta-carotene is synthetic beta-carotene, isolated beta-carotene, or a plant extract containing beta-carotene.

3. The cosmetic composition according to claim 2, wherein the ratio of synthetic beta carotene or isolated beta carotene to sodium polyaspartate is 1:

0.1 to 1;

10.

4. The cosmetic composition according to claim 2, wherein the plant extract is from carrot.

5. The cosmetic composition according to claim 4, wherein the carrot extract is at least one of carrot root extract and carrot seed oil extract.

6. The cosmetic composition according to claim 5, wherein the ratio of carrot extract to sodium polyaspartate is 100:

1 to 10;

1.

7. The cosmetic composition according to claim 6, wherein the ratio of carrot extract to sodium polyaspartate is 40:

1 to 15;

1.

8. The cosmetic composition according to claim 1, wherein the concentration of retinaldehyde is up to 0.1% weight, wherein the weight percentage is based on total composition weight.

9. The cosmetic composition according to claim 1, wherein the retinaldehyde is cyclodextrin encapsulated.

10. A stabilising composition comprising:

beta-carotene;

sodium polyaspartate; and

retinaldehyde, wherein the beta-carotene and sodium polyaspartate stabilise the retinaldehyde.

11. The stabilising composition according to claim 10, wherein the beta-carotene is synthetic beta-carotene, isolated beta-carotene, or a plant extract containing beta-carotene.

12. A method of stabilising retinaldehyde, the method comprising:

providing a composition comprising beta-carotene, sodium polyaspartate, and retinaldehyde.

13. The method according to claim 12, wherein the beta-carotene is synthetic beta-carotene, isolated beta-carotene, or a plant extract containing beta-carotene.

14. The method according to claim 13, wherein the ratio of synthetic beta carotene or isolated beta carotene to sodium polyaspartate is 1:

0.1 to 1;

10.

15. The method according to claim 13, wherein the plant extract is from carrot.

16. The method according to claim 15, wherein the carrot extract at least one of carrot root extract and carrot seed oil extract.

17. The method according to claim 16, wherein the ratio of carrot extract to sodium polyaspartate is 100:

1 to 10;

1.

18. The method according to claim 16, wherein the ratio of carrot extract to sodium polyaspartate is 40:

1 to 15;

1.

19. The method according to claim 12, wherein the concentration of retinaldehyde is up to 0.1% weight, wherein the weight percentage is based on total composition weight.