Method of administration of gamma hydroxybutyrate with monocarboxylate transporters

  • US 10,864,181 B2
  • Filed: 01/10/2019
  • Issued: 12/15/2020
  • Est. Priority Date: 03/01/2013
  • Status: Active Grant
First Claim
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1. A method for the treatment of cataplexy in narcolepsy or excessive daytime sleepiness in narcolepsy in a patient, the method comprising:

  • administering a reduced daily dosage amount of gamma-hydroxybutyrate (GHB) or a salt thereof to a patient who is concomitantly administered divalproex sodium;

    wherein the patient is suffering from cataplexy in narcolepsy or excessive daytime sleepiness in narcolepsy;

    wherein the manufacturer'"'"'s recommended starting daily dosage amount of GHB or salt thereof in the absence of concomitant administration of divalproex sodium is between 4.5 g to 9 g; and

    wherein the reduced daily dosage amount of GHB or salt thereof compensates for pharmacokinetic (PK) and/or pharmacodynamic (PD) changes caused by the divalproex sodium.

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