Apparatus and method for analyzing a material

• US 10,876,965 B2
• Filed: 12/09/2015
• Issued: 12/29/2020
• Est. Priority Date: 12/09/2015
• Status: Active Grant

• Current Assignee: DiaMonTech GmbH
• Original Assignee: DiaMonTech AG
• Inventors: Bauer, Alexander, Hertzberg, Otto, Lubinski, Thorsten
• Primary Examiner(s): Ahmed, Jamil
• Application Number:
  US15/781,176
• Publication Number:
  US 20190302019A1
• Time in Patent Office: 1,847 Days
• CPC Class Codes: A61B 2560/0238 Means for recording calibration data
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: G01N 2021/1712 Thermal lens, mirage effect
• CPC Class Codes: G01N 2021/1725 Modulation of properties by light, e.g. photoreflectance
• CPC Class Codes: G01N 21/171 with calorimetric detection, e.g. with thermal lens detection
• CPC Class Codes: G01N 21/1717 with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
• CPC Class Codes: G01N 21/552 Attenuated total reflection
• CPC Class Codes: G01N 21/636 using an arrangement of pump beam and probe beam; using the measurement of optical non-linear properties; non-linear optics per se G02F1/35
• CPC Class Codes: G01N 2201/06113 Coherent sources; lasers
• CPC Class Codes: G01N 33/49 Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80

Abstract

The invention relates, inter alia, to an apparatus (10) for analyzing a material (101), comprising an excitation emission device (100) for generating at least one electromagnetic excitation beam (SA), in particular an exciting light beam, having at least one excitation wavelength, further comprising a detection device (106) for detecting a reaction signal (SR), and a device (107) for analyzing the material on the basis of the detected reaction signal (SR).

Claims

1. A device for analysing human or animal tissue for non-invasive glucose or blood sugar measurement, said device having

an excitation transmission device for generating at least one excitation light beam with at least one excitation wavelength and radiating the at least one excitation light beam into a tissue volume, which is located underneath a first region of a surface of the tissue,

an optical medium, which in operation is in direct contact with said first region of the surface of the tissue,

a detection device for detecting a response signal, which response signal is attributable to the effect of the wavelength-dependent absorption of the excitation light beam in the tissue,

wherein detecting said response signal comprises one of detecting a measuring beam, after this measuring beam has been reflected at least once at an interface of the optical medium, which is in contact with the first region of the surface of the tissue, and detecting a deformation and/or density change of the optical medium using a piezo element connected to or integrated in said optical medium,

a device for the intensity modulation of the excitation light beam, and

a device for analysing the tissue on the basis of detected response signal, said device being configured for successively determining, using different modulation frequencies of the excitation light beam, response signals, and for combining results obtained with different modulation frequencies with each other and obtaining specific information for a depth range under the surface from this.

2. The device according to claim 1, wherein

the excitation transmission device is a radiation source, a monochromatic, in particular a polarised radiation source, more particularly a laser light source,

wherein the excitation transmission device is preferably arranged such that the emitted excitation beam penetrates the optical medium and exits the same again at a predetermined point on the surface of the optical medium, and

the device comprises a system for emitting a measurement beam, in particular a measurement light beam, which is arranged so that the emitted measurement beam penetrates the optical medium and wherein preferably in operation the measuring beam and the excitation beam overlap at an interface of the optical medium and the surface of the tissue, at which the measuring beam is reflected, and

the detection device is a device for receiving the reflected measuring beam which forms the response signal and/or for directly or indirectly detecting a deflection of the reflected measuring beam.

3. The device according to claim 1, wherein the device comprises an optical medium, which is in direct contact with the tissue, in particular with a first region of the surface of the tissue, and that in order to detect a response signal the detection device detects a parameter change of the optical medium, in particular in a region adjacent to the first region, as a result of the response signal, in particular a deformation and/or density change of the optical medium.

4. The device according to claim 1, wherein the detection device is suitable for detecting a time-dependent response signal as a function of the wavelength of the excitation light and/or the intensity modulation of the excitation light.

5. The device according to claim 1, wherein the excitation transmission device comprises two or more transmission elements, in particular in the form of a one-, two- or multi-dimensional transmission element array.

6. The device according to claim 1, wherein the excitation transmission device comprises two or more lasers, in particular in the form of a one-, two- or multi-dimensional laser array, and/or two or more light-emitting diodes, in particular in the form of a one-, two- or multi-dimensional diode array.

7. The device according to claim 1, wherein the excitation transmission device is directly, or indirectly by means of an adjustment device, mechanically fixedly connected to an optical medium which is in direct contact with the tissue, in particular with the first region of the surface of the tissue.

8. The device according to claim 1, wherein the device for emitting a measuring beam and the detection device are aligned with respect to each other in such a way that the detection device detects the measuring beam as the time-dependent response signal, after this beam has been reflected at least once at the interface of the optical medium, which is in contact with the tissue, in particular with the first region of the surface of the tissue.

9. The device according to claim 1, wherein the device for emitting a measuring beam and/or the detection device and/or the excitation transmission device are directly mechanically fixedly connected to the optical medium and/or coupled to the same by means of a fibre-optic cable.

10. The device according to claim 1, wherein the optical medium directly supports an imaging optics, and/or an imaging optics is integrated into the optical medium.

11. The device according to claim 1, wherein the excitation transmission device and/or the device for the emission of the measuring beam and/or the detection device are directly attached to each other or to a common support.

12. The device according to claim 1, wherein the excitation transmission device has an integrated semiconductor component, which comprises one or more laser elements and at least one micro-optical component and preferably an additional modulation element.

13. A method for analysing human or animal tissue for non-invasive measuring of glucose or blood sugar, wherein in the method

an optical medium is brought into direct contact with a first region of the surface of the tissue,

with an excitation transmission device, at least one electromagnetic excitation light beam with at least one excitation wavelength is generated by an at least partially simultaneous or consecutive operation of a plurality of laser emitters of a laser light source, wherein the intensity of said excitation light beam is modulated at a modulation frequency and said at least one excitation light beam is radiated into a tissue volume, which is located underneath said first region of a surface of the tissue,

with a detection device a response signal is detected, which response signal is attributable to the effect of the wavelength-dependent absorption of the excitation light beam in the tissue, wherein detecting said response signal comprises one of detecting a measuring beam, after this measuring beam has been reflected at least once at an interface of the optical medium, which is in contact with the first region of the surface of the tissue, and detecting a deformation and/or density change of the optical medium using a piezo element connected to or integrated in said optical medium, and the tissue is analysed on the basis of the detected response signal, wherein said analysing the tissue on the basis of the detected response signal comprises successively determining, using different modulation frequencies of the excitation light beam, response signals, and combining results obtained with different modulation frequencies with each other and obtaining specific information for a depth range under the surface from this.

14. The method according to claim 13, wherein

the emitted excitation beam is radiated in such a way that it penetrates the optical medium and exits the same at a predetermined point on the surface of the optical medium, and

with a device for emitting said measuring beam, said measuring beam is generated in such a way that it penetrates the optical medium.

15. The method according to claim 13, wherein as a function of a glucose concentration identified in the tissue, a dosing device is activated for delivering a substance into the tissue, and/or an acoustic and/or visual signal is output and/or a signal is delivered to a processing device via a wireless connection.

16. The method according to claim 14, wherein in operation the measuring beam and the excitation beam overlap at an interface of the optical medium and the surface of the tissue, at which the measuring beam is reflected.

17. The method according to claim 13, wherein the deflection of the reflected measuring beam is directly or indirectly detected.