Pharmaceutical compositions and methods of using the same

  • US 10,894,012 B1
  • Filed: 06/17/2020
  • Issued: 01/19/2021
  • Est. Priority Date: 02/07/2017
  • Status: Active Grant
First Claim
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1. A method of providing induction of local anesthesia of mucous membranes in an adult patient comprising:

  • soaking four pledgets in about 4 mL of a pharmaceutical composition comprising about 36 mg/mL to about 44 mg/mL of cocaine hydrochloride, 1.2 mg/mL to 1.4 mg/mL citric acid, 0.7 mg/mL to 1.3 mg/mL sodium benzoate, and water;

    placing a maximum of two pledgets of the four pledgets in each nasal cavity of an adult patient for about 10 minutes to about 20 minutes, provided that the method results in an AUCinf in a range from about 25.0 ng*h/mL to about 370 ng*h/mL of cocaine in the adult patient; and

    performing a diagnostic or surgical procedure on or through the nasal cavities in the adult patient;

    provided that the method results in a reduction in pain equivalent to achieving a visual numeric rating score of 0 upon von Frey filament testing.

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