Non-invasive method and system for characterizing cardiovascular systems
First Claim
1. A method of extracting variable for use in a machine learning operation to diagnose a pathology, the method comprising:
- receiving, via a processor, a biopotential signal data set associated with a subject, said biopotential signal data set being associated with a biopotential signal collected from one or more electrical leads;
determining, via the processor, a plurality of parameters of dynamical features of the received biopotential signal data set for a dictionary that estimates a model of the received biopotential signal data set, wherein the plurality of dynamical features includes Lyapunov exponent and correlation dimension features; and
linking, via the processor, the plurality of determined parameters of the dynamical features to a genetic algorithm for producing outputs that correlate with clinical parameters describing tissue architecture, structure and/or function.
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Abstract
The present disclosure uses physiological data, ECG signals as an example, to evaluate cardiac structure and function in mammals. Two approaches are presented, e.g., a model-based analysis and a space-time analysis. The first method uses a modified Matching Pursuit (MMP) algorithm to find a noiseless model of the ECG data that is sparse and does not assume periodicity of the signal. After the model is derived, various metrics and subspaces are extracted to image and characterize cardiovascular tissues using complex-sub-harmonic-frequencies (CSF) quasi-periodic and other mathematical methods. In the second method, space-time domain is divided into a number of regions, the density of the ECG signal is computed in each region and inputted into a learning algorithm to image and characterize the tissues.
10 Citations
20 Claims
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1. A method of extracting variable for use in a machine learning operation to diagnose a pathology, the method comprising:
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receiving, via a processor, a biopotential signal data set associated with a subject, said biopotential signal data set being associated with a biopotential signal collected from one or more electrical leads; determining, via the processor, a plurality of parameters of dynamical features of the received biopotential signal data set for a dictionary that estimates a model of the received biopotential signal data set, wherein the plurality of dynamical features includes Lyapunov exponent and correlation dimension features; and linking, via the processor, the plurality of determined parameters of the dynamical features to a genetic algorithm for producing outputs that correlate with clinical parameters describing tissue architecture, structure and/or function. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A system to extract variable for use in machine learning operation to diagnose a pathology, the system comprising:
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a processor; a memory having instructions stored thereon, wherein execution of the instructions by the processor causes the processor to; receive a biopotential signal data set associated with a subject, said biopotential signal data set being associated with a biopotential signal collected from one or more electrical leads; determine a plurality of parameters of dynamical features of the received biopotential signal data set for a dictionary that estimates a model of the received biopotential signal data set, wherein the plurality of dynamical features includes Lyapunov exponent and correlation dimension; and link the plurality of determined parameters of the dynamical features to a genetic algorithm for producing outputs that correlate with clinical parameters describing tissue architecture, structure and/or function. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18)
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19. A non-transitory computer readable medium having instructions stored thereon, wherein execution of the instructions by a processor causes the processor to:
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receive a biopotential signal data set associated with a subject, said biopotential signal data set being associated with a biopotential signal collected from one or more electrical leads; determine a plurality of parameters of dynamical features of the received biopotential signal data set for a dictionary that estimates a model of the received biopotential signal data set, wherein the plurality of dynamical features includes Lyapunov exponent and correlation dimension features; and link the plurality of determined parameters of the dynamical features to a genetic algorithm for producing outputs that correlate with clinical parameters describing tissue architecture, structure and/or function. - View Dependent Claims (20)
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Specification