Celecoxib and amlodipine formulation and method of making the same

  • US 10,945,960 B2
  • Filed: 05/31/2019
  • Issued: 03/16/2021
  • Est. Priority Date: 07/06/2017
  • Status: Active Grant
First Claim
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1. A pharmaceutical composition comprising:

  • (i) an admixture comprisinga dry granulate comprising celecoxib or a pharmaceutically acceptable salt, wherein the dry granulate has a loss on drying (LOD) % of about 2.5% or less, wherein said dry granulate does not include amlodipine; and

    an extragranulate comprising amlodipine or a pharmaceutically acceptable salt thereof admixed with the dry granulate; and

    (ii) one or more excipients selected from the group consisting of a diluent, a disintegrant, a surfactant, a binder, a glidant, a lubricant, and combinations thereof.

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