Implantable prosthesis having acellular tissue attachments

• US 10,959,833 B2
• Filed: 07/30/2018
• Issued: 03/30/2021
• Est. Priority Date: 06/21/2012
• Status: Active Grant

• Current Assignee: Lifecell Corporation (Abbvie Incorporated)
• Original Assignee: Lifecell Corporation (Abbvie Incorporated)
• Inventors: Ansorge, Heather, Lapitan, Lawrence, Hayzlett, Mark, Kabaria, Nimesh, Hull, Raymond, Sun, Wenquan, Taenzer, Michael, Amato, Matthew, Roock, Timothy, Lee, Dennis
• Primary Examiner(s): Sharma, Yashita
• Application Number:
  US16/049,089
• Publication Number:
  US 20180333252A1
• Time in Patent Office: 974 Days
• CPC Class Codes: A61B 90/02 Devices for expanding tissue, e.g. skin tissue implements for holding wounds open, surgical tractors A61B17/02; implantable mammary prosthesis A61F2/12; dilators A61M29/00
• CPC Class Codes: A61F 2/0059 Cosmetic or alloplastic implants A61F2/10 - A61F2/16, A61F2/28 take precedence
• CPC Class Codes: A61F 2/12 Mammary prostheses and implants
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2210/009 magnetic
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/0025 Connections or couplings between prosthetic parts, e.g. between modular parts; Connecting elements
• CPC Class Codes: A61F 2220/0033 made by longitudinally pushing a protrusion into a complementary-shaped recess, e.g. held by friction fit
• CPC Class Codes: A61F 2220/005 using adhesives
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2220/0091 connected by a hinged linkage mechanism, e.g. of the single-bar or multi-bar linkage type
• CPC Class Codes: A61F 2230/0004 Rounded shapes, e.g. with rounded corners
• CPC Class Codes: A61F 2230/0045 Omega-shaped
• CPC Class Codes: A61F 2230/0086 Pyramidal, tetrahedral, or wedge-shaped
• CPC Class Codes: A61F 2230/0089 tetrahedral, i.e. having a triangular basis
• CPC Class Codes: A61F 2230/0093 Umbrella-shaped, e.g. mushroom-shaped
• CPC Class Codes: A61F 2250/0003 having an inflatable pocket filled with fluid, e.g. liquid or gas
• CPC Class Codes: A61F 2250/0024 made from both porous and non-porous parts, e.g. adjacent parts
• CPC Class Codes: A61F 2250/0031 made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
• CPC Class Codes: A61F 2250/0051 differing in tissue ingrowth capacity, e.g. made from both ingrowth-promoting and ingrowth-preventing parts
• CPC Class Codes: A61F 2250/0071 : breakable or frangible

Abstract

Improved prostheses comprising a tissue expander and a graft material are disclosed herein. Also disclosed are methods of making prostheses and methods of treatment using the prostheses.

Claims

1. A prosthesis comprising:

a tissue expander; and

one or more samples of graft material releasably coupleable to the tissue expander in a manner that allows the tissue expander and the graft material to be implanted in a patient as a unitary prosthesis and in a manner that will permit the tissue expander to separate from the graft material after a period of time following implantation to allow removal of the tissue expander from an implant site while leaving the graft material within the implant site;

wherein the prosthesis comprises one or more elongated fasteners to secure the graft material to the tissue expander; and

wherein the graft material is configured to release from the tissue expander due to tension on the one or more elongated fasteners, the tension caused by enlargement of the tissue expander after implantation.

2. The prosthesis of claim 1, wherein the one or more samples of graft material comprise acellular tissue matrix.

3. The prosthesis of claim 1, wherein the one or more samples of graft material comprise dermal tissue matrix.

4. The prosthesis of claim 2, wherein the acellular tissue matrix comprises an adipose acellular tissue matrix.

5. The prosthesis of claim 1, wherein the one or more elongated fasteners comprise silicone.

6. The prosthesis of claim 1, wherein the one or more elongated fasteners comprise a resorbable synthetic material.

7. The prosthesis of claim 6, wherein the one or more elongated fasteners dissolve over a period of time following implantation after exposure to an aqueous implant environment such that the tissue expander is released from the graft material.

8. The prosthesis of claim 1, wherein the one or more samples of graft material comprise one or more holes, slits, or apertures through which the one or more elongated fasteners are passed to secure the graft material to the tissue expander.

9. The prosthesis of claim 1, wherein the tissue expander comprises exactly two elongated fasteners that can be passed through holes in the graft material to secure the graft material to the tissue expander.