Composition and method for vancomycin oral liquid

  • US 10,959,948 B2
  • Filed: 07/28/2020
  • Issued: 03/30/2021
  • Est. Priority Date: 03/14/2014
  • Status: Active Grant
First Claim
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1. A non-sterile stable liquid formulation formulated for oral administration, consisting of:

  • (a) a buffering agent, wherein the buffering agent is selected from the group consisting of citric acid, sodium citrate, sodium tartarate, sodium acetate, sodium carbonate, sodium polyphosphate, potassium polyphosphate, sodium pyrophosphate, potassium pyrophosphate, disodium hydrogen phosphate, trisodium phosphate, tripotassium phosphate, sodium acetate, potassium metaphosphate, magnesium oxide, magnesium carbonate, magnesium silicate, calcium acetate, calcium glycerophosphate, calcium chloride, calcium hydroxide, calcium lactate, calcium carbonate, calcium bicarbonate, and calcium salts,(b) water,(c) a sweetener,(d) sodium benzoate,(e) vancomycin hydrochloride, and(f) flavoring agent,wherein the non-sterile stable liquid formulation is homogenous and stable for at least 1 week at ambient and refrigerated temperature and has a pH of 2.5-4.5.

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