Methods for treating pancreatic cancer using combination therapies comprising liposomal irinotecan

  • US 10,980,795 B2
  • Filed: 06/19/2018
  • Issued: 04/20/2021
  • Est. Priority Date: 06/13/2012
  • Status: Active Grant
First Claim
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1. A method of treating metastatic adenocarcinoma of the pancreas in a human patient who has previously been treated with gemcitabine, comprising intravenously administering an antineoplastic therapy to the patient once every two weeks, the therapy consisting ofi) irinotecan sucrose octasulfate salt liposome injection in a dose providing the equivalent of 70 mg/m2 of irinotecan free base,ii) 200 mg/m2 of the (l) form of leucovorin or 400 mg/m2 of the (l+d) racemic form of leucovorin, andiii) 2400 mg/m2 of 5-fluorouracil.

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