Compositions and methods for the treatment of pain

• US 10,987,365 B2
• Filed: 10/01/2013
• Issued: 04/27/2021
• Est. Priority Date: 10/01/2012
• Status: Active Grant

• Current Assignee: Gm Pharmaceuticals, Inc.
• Original Assignee: Gm Pharmaceuticals, Inc.
• Inventors: Mitchell, Odes W.
• Primary Examiner(s): Ricci, Craig D
• Application Number:
  US14/043,722
• Publication Number:
  US 20140094438A1
• Time in Patent Office: 2,765 Days
• Field of Search: None
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/045 Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
• CPC Class Codes: A61K 31/09 having two or more such linkages
• CPC Class Codes: A61K 31/125 Camphor; Nuclear substituted derivatives thereof
• CPC Class Codes: A61K 31/135 having aromatic rings , e.g. ketamine, nortriptyline methadone A61K31/137
• CPC Class Codes: A61K 31/137 Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
• CPC Class Codes: A61K 31/167 having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
• CPC Class Codes: A61K 31/194 having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
• CPC Class Codes: A61K 31/4402 only substituted in position 2, e.g. pheniramine, bisacodyl
• CPC Class Codes: A61K 31/495 having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazinesA61K31/48 takes precedence ; with three nitrogen atoms A61K31/53
• CPC Class Codes: A61K 31/505 Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
• CPC Class Codes: A61K 31/522 having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
• CPC Class Codes: A61K 31/60 Salicylic acid; Derivatives thereof
• CPC Class Codes: A61K 31/616 by carboxylic acids, e.g. acetylsalicylic acid

Abstract

The claimed invention relates to compositions that may be in a form of a liquid, solid, gel, cream or gel capsule comprising an analgesic, and methods for administering these compositions for treatment of patients suffering from various forms of pain.

Claims

1. A composition comprising:

(a) an analgesic/antipyretic combination comprising about 435 mg to about 1,338 mg choline salicylate and about 10 wt % trolamine salicylate based on the total weight of the composition;

(b) at least one analgesic adjunct comprising about 1 mg to about 200 mg caffeine;

(c) an antihistamine comprising about 1 mg to about 200 mg pyrilamine tannate;

(d) a diuretic agent comprising pamabrom; and

(e) an antifoaming agent comprising simethicone;

wherein the composition is a cream.

2. The composition of claim 1, wherein said composition further comprises a flavorant.

3. The composition of claim 1, wherein an amount of the caffeine is 60 mg.

4. The composition of claim 1, wherein an amount of the caffeine is 65 mg.

5. The composition of claim 1, wherein the composition is dissolved in a buffering salt.