Method and system for determining a measurement start time

• US 11,020,081 B2
• Filed: 05/07/2014
• Issued: 06/01/2021
• Est. Priority Date: 06/07/2013
• Status: Active Grant

• Current Assignee: Siemens Healthineers AG (Siemens AG)
• Original Assignee: Siemens AG
• Inventors: Korporaal, Johannes Georg
• Primary Examiner(s): Blaise, Malina D.
• Application Number:
  US14/892,221
• Publication Number:
  US 20160089100A1
• Time in Patent Office: 2,582 Days
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: A61B 5/145 Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissuemeasuring of blood pressure or blood flow A61B5/02; non-radiation detecting or locating of foreign bodies in blood A61B5/06
• CPC Class Codes: A61B 5/7278 Artificial waveform generation or derivation, e.g. synthesising signals from measured signals A61B5/327 takes precedence
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/481 involving the use of contrast agents
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography
• CPC Class Codes: A61B 6/54 Control of apparatus or devices for radiation diagnosis
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal
• CPC Class Codes: A61B 8/481 involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream analysis of echo signal exploiting properties of a contrast enhancer in devices for short-range imaging with acoustic waves G01S7/52039
• CPC Class Codes: A61B 8/543 involving acquisition triggered by a physiological signal

Abstract

A method is disclosed for determining a measurement start time for an imaging measurement via a medical imaging system depending on a course of concentration values of a contrast medium in a monitored region of an examination object over time. The method includes detecting the concentration values of the current concentration of the contrast medium in the monitored region at different successive detection times; determining a current examination-specific accumulation model curve on the basis of a course of the concentration values over time; and determining the measurement start time on the basis of the examination-specific accumulation model curve. A method for controlling a medical imaging system, a control device and a medical imaging system for implementing the method are further disclosed.

Claims

1. A method for determining a measurement start time for an imaging measurement via a medical imaging system, the method comprising:

respectively detecting concentration values of a current concentration of a contrast medium in a monitored region of an examination subject at successive detection times;

determining a current examination-specific enhancement model curve based on a behavior of the concentration values with respect to time and a plurality of candidate enhancement model curves, the plurality of candidate enhancement model curves being calculated based on a population-averaged enhancement model curve; and

determining the measurement start time based on the current examination-specific enhancement model curve,

wherein the determining a current examination-specific enhancement model curve includes,

fitting the concentration values with respect to time to each of the plurality of candidate enhancement model curves, and

selecting the current examination-specific enhancement model curve from among the plurality of candidate enhancement model curves based on the fitting.

2. The method of claim 1, wherein the determining a current examination-specific enhancement model curve is further based on a population-averaged contrast medium impulse response function.

3. The method of claim 2, further comprising:

acquiring injection protocol data, wherein

the determining a current examination-specific enhancement model curve is further based on the injection protocol data.

4. The method of claim 2, wherein a correction factor of each respective one of the plurality of candidate enhancement model curves is chosen such that candidate enhancement model curves having different widths have a substantially identical integral value.

5. The method of claim 2, wherein a correction factor is based on at least one of a current iodine concentration of the contrast medium or a current tube voltage of a computed tomography system used for a current measurement.

6. A method for activating a medical imaging system to generate image data of an examination subject, the method comprising:

determining a measurement start time according to the method of claim 2; and

activating the medical imaging system to generate image data of an examination subject based on the measurement start time.

7. A non-transitory computer readable medium, loadable directly into a memory of a control device of a medical imaging system, the non-transitory computer readable medium including program code segments for performing the method of claim 2 when executed on the control device.

8. The method of claim 1, further comprising:

acquiring injection protocol data, and wherein

the determining a current examination-specific enhancement model curve is further based on the injection protocol data.

9. The method of claim 1, wherein the plurality of candidate enhancement model curves are parameterized by different widths.

10. The method of claim 9, wherein a correction factor of each respective one of the plurality of candidate enhancement model curves is chosen such that candidate enhancement model curves having different widths have a substantially identical integral value.

11. The method of claim 10, wherein the correction factor is based on at least one of a current iodine concentration of the contrast medium or a current tube voltage of a computed tomography system used for a current measurement.

12. The method of claim 1, wherein the population-averaged enhancement model curve includes at least one of a gender-specific population-averaged enhancement model curve, a weight-specific population-averaged enhancement model curve, a size-specific population-averaged enhancement model curve, a defect-specific population-averaged enhancement model curve or an age-specific population-averaged enhancement model curve.

13. The method of claim 1, wherein the plurality of candidate enhancement model curves are parameterized by at least one correction factor.

14. The method of claim 13, wherein the at least one correction factor is based on at least one of a current iodine concentration of the contrast medium or a current tube voltage of a computed tomography system used for a current measurement.

15. The method of claim 13, wherein a respective correction factor among the at least one correction factor is chosen for each of the plurality of candidate enhancement model curves such that candidate enhancement model curves having different widths have a substantially identical integral value.

16. A method for activating a medical imaging system to generate image data of an examination subject, the method comprising:

determining a measurement start time for an imaging measurement according to the method of claim 1; and

activating the medical imaging system to generate image data of the examination subject based on the measurement start time.

17. The method of claim 16, wherein the activating the medical imaging system comprises:

performing an imaging measurement of a target region of the examination subject based on the measurement start time.

18. A non-transitory computer readable medium, loadable directly into a memory of a control device of a medical imaging system, the non-transitory computer readable medium including program code segments for performing the method of claim 16 when executed on the control device.

19. A non-transitory computer readable medium, loadable directly into a memory of a control device of a medical imaging system, the non-transitory computer readable medium including program code segments for performing the method of claim 1 when executed on the control device.

20. The method of claim 1, wherein the selecting selects a closest fitting candidate enhancement model curve from among the plurality of candidate enhancement model curves as the current examination-specific enhancement model curve based on the fitting.

21. The method of claim 1, wherein the concentration values include at least two data values with respect to time, and each of the candidate enhancement model curves includes at least two data values with respect to time.

22. The method of claim 1, wherein each of the plurality of candidate enhancement model curves has a parameter corresponding to cardiac output, and each of the plurality of candidate enhancement model curves has a different value of the parameter.

23. The method of claim 22, wherein the parameter corresponds to a width of a respective candidate enhancement model curve among the plurality of candidate enhancement model curves in a time dimension.

24. A method for performing an imaging measurement via a medical imaging system, the method comprising:

respectively detecting concentration values of a current concentration of a contrast medium in a monitored region of an examination subject at successive detection times;

determining a current examination-specific enhancement model curve based on a behavior of the concentration values with respect to time and a plurality of candidate enhancement model curves, the plurality of candidate enhancement model curves being calculated based on a population-averaged enhancement model curve;

determining a measurement start time for the imaging measurement based on the current examination-specific enhancement model curve; and

performing the imaging measurement at the measurement start time after the determining the measurement start time, wherein

the determining a current examination-specific enhancement model curve includes fitting the plurality of candidate enhancement model curves to the behavior of the concentration values with respect to time.

25. The method of claim 24, wherein the fitting comprises at least one of:

shifting the plurality of candidate enhancement model curves relative to the concentration values with respect to a reference concentration value;

or

shifting the plurality of candidate enhancement model curves relative to the concentration values with respect to a reference time.

26. A control device for a medical imaging system, the control device comprising:

an interface configured to acquire or output a contrast medium administration start time; and

a measurement start time determination unit including

an input interface configured to respectively acquire concentration values of a current concentration of a contrast medium in a monitored region of an examination subject at successive detection times,

an enhancement model curve determination unit configured to determine a current examination-specific enhancement model curve based on a behavior of the concentration values with respect to time and a plurality of candidate enhancement model curves, the plurality of candidate enhancement model curves being calculated based on a population-averaged enhancement model curve, and

a model curve analysis unit configured to determine the measurement start time based on the current examination-specific enhancement model curve, wherein

the enhancement model curve determination unit is configured to determine the current examination-specific enhancement model curve by,

fitting the concentration values with respect to time to each of the plurality of candidate enhancement model curves, and

selecting the current examination-specific enhancement model curve from among the plurality of candidate enhancement model curves based on the fitting.

27. A medical imaging system for generating image data of a target region located inside an examination subject, the medical imaging system comprising the control device of claim 26.