Single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate

  • US 11,033,839 B2
  • Filed: 12/03/2018
  • Issued: 06/15/2021
  • Est. Priority Date: 08/29/2014
  • Status: Active Grant
First Claim
Patent Images

1. A method of filtering a liquid feed, comprising:

  • a) passing a liquid feed in a single pass mode through a single pass tangential flow filtration (SPTFF) system that comprises;

    a plurality of stacked filtration modules that are fluidly connected, each filtration module comprising;

    a single manifold segment comprising a first manifold for receiving and carrying the feed into the filtration module, a second manifold for receiving and carrying retentate out of the filtration module, and a third manifold for receiving and carrying permeate through the filtration module; and

    a plurality of TFF cassettes that are stacked on one or both faces of, and are fluidly connected to, the manifold segment, wherein each manifold segment is stacked with the adjoining manifold segment and the manifolds in any adjoining manifold segment in adjacent filtration modules are coupled to create a centralized serial flow path through the system for feed and retentate;

    a feed inlet on the first filtration module in the system; and

    a retentate outlet on the last filtration module in the system,wherein at least one filtration module further comprises valves on flow channels between the TFF cassettes, wherein the cassettes are processed in parallel when the valves are open, or in series when the valves are closed;

    the SPTFF system having a liquid flow path that is parallel through the cassettes in each filtration module and serial through each manifold segment in adjacent filtration modules by coupling the first manifold in each manifold segment to the second manifold of an adjacent manifold segment, such that the retentate of one module serves as the feed for the manifold segment of the next filtration module, except that the first manifold in the manifold segment of the first filtration module in the system is connected to the feed inlet and the second manifold in the manifold segment of the last filtration module in the system is connected to the retentate outlet; and

    b) recovering the retentate and permeate from the system in separate containers without recirculation through the SPTFF system, thereby filtering the liquid feed.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×