Single-pass filtration systems and processes

  • US 11,040,310 B2
  • Filed: 12/03/2018
  • Issued: 06/22/2021
  • Est. Priority Date: 06/16/2014
  • Status: Active Grant
First Claim
Patent Images

1. A method of adding a processing unit to a single-pass tangential flow filtration (SPTFF) assembly, the method comprising:

  • a) establishing a fluid connection between a first processing unit in the SPTFF assembly and a second processing unit that is to be added to the SPTFF assembly, wherein the first and second processing units each comprise a cassette holder containing at least one TFF cassette and wherein the cassette holders of the first and second processing units are fluidly connected to each other by a first channel connected to a feed inlet, a second channel connected to a retentate outlet and a permeate channel, wherein the first channel, the second channel and the permeate channel in adjacent processing units are fluidly aligned, and wherein the first channel, second channel and permeate channel extend through the cassette holders of the first and second processing units; and

    b) positioning a valve on the first channel between the first and second cassette holders of the processing units, and a spool piece or valve on the second channel between the first and second cassette holders, thereby preventing feed in the first channel in the first processing unit from flowing directly into the second processing unit when the valve on the first channel is closed and ensuring that the first and second processing units are processed in series.

View all claims
    ×
    ×

    Thank you for your feedback

    ×
    ×