Solution comprising nicotine in unprotonated form and protonated form

• US 11,044,937 B2
• Filed: 11/06/2015
• Issued: 06/29/2021
• Est. Priority Date: 11/07/2014
• Status: Active Grant

• Current Assignee: Nicoventures Trading Ltd. (British American Tobacco PLC)
• Original Assignee: Nicoventures Trading Ltd. (British American Tobacco PLC)
• Inventors: McAdam, Kevin Gerard, Bruton, Connor
• Primary Examiner(s): Yaary, Eric
• Application Number:
  US15/525,194
• Publication Number:
  US 20180279667A1
• Time in Patent Office: 2,062 Days
• CPC Class Codes: A24B 15/16 of tobacco substitutes
• CPC Class Codes: A24B 15/167 in liquid or vaporisable form, e.g. liquid compositions for electronic cigarettes
• CPC Class Codes: A24B 15/301 by aromatic compounds
• CPC Class Codes: A24F 40/10 Devices using liquid inhalable precursors
• CPC Class Codes: A24F 40/40 Constructional details, e.g. connection of cartridges and battery parts
• CPC Class Codes: A61K 31/465 Nicotine; Derivatives thereof
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 9/0073 Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy; nasal sprays A61K9/0043; inhalation of vapours of volatile or heated drugs, e.g. essential oils or nicotine, A61K9/007; devices A61M
• CPC Class Codes: A61K 9/0078 for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
• CPC Class Codes: A61K 9/08 Solutions composition of solutions A61K47/00

Abstract

There is provided a nicotine solution, including a carrier; nicotine in unprotonated form and in protonated form; and one or more acids, wherein at least benzoic acid, levulinic acid or a mixture thereof is present; and wherein the total content of acid present in the solution is no greater than 0.6 mole equivalents based on the nicotine.

Claims

1. A cartomizer containing a nicotine solution and a heating element, the nicotine solution comprising:

(i) a carrier;

(ii) nicotine in unprotonated form and in protonated form, wherein nicotine is present in an amount of from 1.8 to 6 wt% based on the total weight of the solution; and

(iii) an acid selected from the group consisting of benzoic acid; and

wherein the total content of acid present in the solution is between 0.3 and 0.6 mole equivalents based on the nicotine.

2. The cartomizer according to claim 1 wherein the nicotine solution further comprises water.

3. The cartomizer according to claim 1 comprising nicotine in an amount of no greater than 2 wt% based on the total weight of the nicotine solution.

4. The cartomizer according to claim 1 wherein the carrier is a solvent.

5. The cartomizer according to claim 4 wherein the solvent is selected from glycerol, propylene glycol and mixtures thereof.