Composite sensor assemblies for single use bioreactors
First Claim
Patent Images
1. A composite assembly for use with a polymeric bioprocess vessel, the composite assembly comprising:
- a bioprocess vessel including a wall having an opening;
a port including a high surface tension thermoplastic, wherein the port includes a hollow tubular portion and a base plate portion, the base plate includes a polymer fused to the bioprocess vessel at the opening in the wall; and
a polymeric unit adhesively retained within the bore of the hollow tubular portion of the port, wherein the port provides the polymeric unit with access to contents of the polymeric bioreactor vessel.
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Abstract
A composite sensor assembly for monitoring bio-processes which is suitable for use with a polymeric bioprocess vessel or with downstream equipment, and comprises:
- i) a port comprising a high surface tension thermoplastic having a hollow tubular portion and a base plate portion, the base plate being fusibly sealable to the bioreactor vessel at a hole in the wall thereof;
- ii) a generally opaque polymeric monitoring sensor assembly including electrical, and/or optical measurement components. The sensor assembly fits inside the bore of the hollow tubular portion of the port, and is adhesively retained therein.
38 Citations
20 Claims
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1. A composite assembly for use with a polymeric bioprocess vessel, the composite assembly comprising:
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a bioprocess vessel including a wall having an opening; a port including a high surface tension thermoplastic, wherein the port includes a hollow tubular portion and a base plate portion, the base plate includes a polymer fused to the bioprocess vessel at the opening in the wall; and a polymeric unit adhesively retained within the bore of the hollow tubular portion of the port, wherein the port provides the polymeric unit with access to contents of the polymeric bioreactor vessel. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A composite sensor assembly for bioproduction, comprising:
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a polymeric bioprocess vessel including an opening; a flexible port comprising a high surface tension thermoplastic, wherein the flexible port has a hollow tubular portion and a base plate portion and the base plate is fused to the opening in the polymeric bioprocess vessel; and a polymeric sensor unit including measurement components, wherein the sensor unit fits inside and is adhered to the bore of the hollow tubular portion of the flexible port, wherein the port provides the measurement components with access to contents of the polymeric bioprocess vessel.
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20. A composite sensor assembly for bioproduction, comprising:
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a polymeric bioprocess vessel including an opening; a flexible port comprising a high surface tension thermoplastic, wherein the flexible port has a hollow tubular portion and a base plate portion and the base plate is fused to the opening in the polymeric bioprocess vessel; and a polymeric sensor unit adhered to the inside of the bore of the hollow tubular portion of the flexible port, wherein the port provides a fluorescent dye spot on the polymeric sensor unit with access to contents of the polymeric bioprocess vessel.
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Specification