Medical hydrogel composition, and medical hydrogel, preparation method therefor and application thereof

• US 11,065,360 B2
• Filed: 04/28/2017
• Issued: 07/20/2021
• Est. Priority Date: 04/29/2016
• Status: Active Grant

• Current Assignee: Medprin Regenerative Medical Technologies Co., Ltd.
• Original Assignee: Medprin Regenerative Medical Technologies Co., Ltd.
• Inventors: Lin, Limin, Yang, Yaya, Ma, Cheng, Deng, Kunxue, Yuan, Yuyu
• Primary Examiner(s): Phan, Doan T
• Application Number:
  US16/097,473
• Publication Number:
  US 20190142994A1
• Time in Patent Office: 1,544 Days
• CPC Class Codes: A61L 24/0015 Medicaments; Biocides
• CPC Class Codes: A61L 24/0031 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 24/043 Mixtures of macromolecular materials
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/26 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/041 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61L 31/145 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 31/148 Materials at least partially resorbable by the body
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: C08L 77/04 Polyamides derived from alpha-amino carboxylic acids C08L77/10 takes precedence
• CPC Class Codes: C08L 79/02 Polyamines

Abstract

A medical hydrogel composition, a medical hydrogel, a preparation method therefore and an application thereof, and a medical hydrogel kit. The medical hydrogel composition comprises a first component and a second component; the first component comprises polylysine and polyethylene imine; the second component comprises one or more of 4-arm-polyethylene glycol-succinimidyl glutarate, 4-arm-polyethylene glycol-succinimidyl succinate, and 4-arm-polyethylene glycol-succinimidyl carbonate; the degree of polymerization of the polylysine is 20 or more. The medical hydrogel is formed by reacting the first component with the second component of the medical hydrogel composition. The medical hydrogel kit comprises the medical hydrogel composition and a buffer solution used for dissolving the components of the medical hydrogel composition. The medical hydrogel has a degree of swelling of −10%-50%, and can be applied in narrow parts where cranial, spinal, and peripheral nerves are densely distributed.

Claims

1. A medical hydrogel kit, comprising:

a first component comprising polylysine and polyethylene imine (PEI), wherein the polylysine is ε

-polylysine having an average molecular weight of 3000 to 5000 Da or poly-L-lysine having an average molecular weight of 7500 to 300000 Da, the polylysine has a degree of polymerization of 20 or more, and the polylysine and the PEI have a mass ratio of 0.1 to 1;

a second component selected from the group consisting of 4-arm-polyethylene glycol-succinimidyl glutarate, 4-arm-polyethylene glycol-succinimidyl succinate, 4-arm-polyethylene glycol-succinimidyl carbonate, and combinations thereof, wherein the second component has an average molecular weight of 10,000 to 20,000 Da; and

a saline solution,

wherein the first component, the second component and the saline solution react to form a medical hydrogel having a degree of swelling of 5% to 47% when mixed together, and

wherein the formed medical hydrogel has a complete in vivo degradation time from 5 to 8 weeks.

2. The medical hydrogel kit according to claim 1, wherein the first component and the second component are stored separately.

3. The medical hydrogel kit according to claim 1, wherein the saline solution has a pH of 7.0 to 7.4.