Formulations of bendamustine

  • US 11,103,483 B2
  • Filed: 07/12/2019
  • Issued: 08/31/2021
  • Est. Priority Date: 01/28/2010
  • Status: Active Grant
First Claim
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1. A ready to use liquid bendamustine-containing composition comprisingbendamustine, or a pharmaceutically acceptable salt thereof, wherein the bendamustine concentration in the composition is from about 10 mg/mL to about 100 mg/mL;

  • polyethylene glycol; and

    a stabilizing amount of an antioxidant;

    the composition having less than about 5% peak area response of total impurities resulting from the degradation of the bendamustine, as determined by HPLC as a wavelength of 223 nm after at least 15 months at a temperature of from about 5°

    C. to about 25°

    C.

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