Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications
First Claim
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1. A nanostructure, comprising a liposomal core having a lipid bilayer and oligonucleotides, wherein all the oligonucleotides are single-stranded B-class CpG oligonucleotides positioned on the exterior of the liposomal core in the form of an oligonucleotide shell, and wherein each oligonucleotide is indirectly linked to the liposomal core through a lipid anchor.
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Abstract
Liposomal spherical nucleic acids that function as multivalent immune modulators are provided according to the invention. The liposomal spherical nucleic acids of the invention are useful prophylactic and therapeutic applications as well as research and diagnostic indications.
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33 Claims
- 1. A nanostructure, comprising a liposomal core having a lipid bilayer and oligonucleotides, wherein all the oligonucleotides are single-stranded B-class CpG oligonucleotides positioned on the exterior of the liposomal core in the form of an oligonucleotide shell, and wherein each oligonucleotide is indirectly linked to the liposomal core through a lipid anchor.
- 27. A method for treating a disease or disorder in a subject, the method comprising administering a nanostructure comprising a liposomal core having a lipid bilayer and oligonucleotides to stimulate the immune system of a subject to treat a disease or disorder in the subject, wherein all the oligonucleotides are single-stranded B-class CpG oligonucleotides positioned on the exterior of the liposomal core in the form of an oligonucleotide shell, and wherein each oligonucleotide is indirectly linked to the liposomal core through a lipid anchor.
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