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Multivalent delivery of immune modulators by liposomal spherical nucleic acids for prophylactic or therapeutic applications

  • US 11,123,294 B2
  • Filed: 09/12/2019
  • Issued: 09/21/2021
  • Est. Priority Date: 06/04/2014
  • Status: Active Grant
First Claim
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1. A nanostructure, comprising a liposomal core having a lipid bilayer and oligonucleotides, wherein all the oligonucleotides are single-stranded B-class CpG oligonucleotides positioned on the exterior of the liposomal core in the form of an oligonucleotide shell, and wherein each oligonucleotide is indirectly linked to the liposomal core through a lipid anchor.

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