Method and apparatus for providing data processing and control in a medical communication system

• US 11,125,592 B2
• Filed: 07/19/2018
• Issued: 09/21/2021
• Est. Priority Date: 05/14/2007
• Status: Active Grant

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Hayter, Gary Alan, McGarraugh, Geoffrey V., Naegeli, Andrew H., Mazza, John Charles, Feldman, Benjamin Jay
• Primary Examiner(s): Weare, Meredith
• Application Number:
  US16/040,451
• Publication Number:
  US 20180328766A1
• Time in Patent Office: 1,160 Days
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2560/0252 using ambient temperature
• CPC Class Codes: A61B 5/0004 characterised by the type of physiological signal transmitted
• CPC Class Codes: A61B 5/002 Monitoring the patient using a local or closed circuit, e.g. in a room or building A61B5/0017 takes precedence
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/7221 Determining signal validity, reliability or quality A61B5/7207 and A61B5/7217 take precedence
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: G01D 18/008 with calibration coefficients stored in memory
• CPC Class Codes: G01N 33/48 Biological material, e.g. blood, urine G01N33/02, G01N33/26, G01N33/44, G01N33/46 take precedence; Haemocytometers counting blood corpuscules distributed over a surface by scanning the surface G06M11/02
• CPC Class Codes: G16H 15/00 ICT specially adapted for medical reports, e.g. generation or transmission thereof
• CPC Class Codes: G16H 20/17 delivered via infusion or injection
• CPC Class Codes: G16H 40/40 for the management of medical equipment or devices, e.g. scheduling maintenance or upgrades
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

Methods and apparatus for providing data processing and control for use in a medical communication system are provided.

Claims

1. A method, comprising:

storing a current value associated with a monitored glucose level;

retrieving one or more stored values associated with the monitored glucose level, including at least the current value and one or more prior values corresponding to measurements taken by an analyte sensor over a predetermined period of time;

determining a rate of change estimate based on the current value and the one or more prior values;

determining a number of unavailable values of the one or more stored values associated with the monitored glucose level;

calculating an uncertainty parameter associated with the determined rate of change estimate based on the number of unavailable values of the one or more stored values;

determining whether the uncertainty parameter is within a predetermined tolerance range;

when the uncertainty parameter is not within the predetermined tolerance range, discarding the determined rate of change estimate; and

when the uncertainty parameter is within the tolerance range, assigning the determined rate of change estimate to a selected bin of a plurality of predetermined bins, and displaying a trend arrow according to the selected bin.

2. The method of claim 1, wherein the uncertainty parameter is dynamically configured according to a number of the one or more stored values available for the determining of the rate of change estimate.

3. The method of claim 1, wherein calculating the uncertainty parameter is at least based on a user specified parameter.

4. The method of claim 1, wherein the predetermined tolerance range corresponds to an unacceptable number of the one or more stored values being corrupt, unusable or unavailable.

5. The method of claim 1, further comprising obtaining the monitored glucose level by an in vivo sensor comprising a plurality of electrodes including a working electrode comprising an analyte-responsive enzyme bonded to a polymer disposed on the working electrode.

6. The method of claim 5, wherein the analyte-responsive enzyme is chemically bonded to the polymer.

7. The method of claim 5, wherein the working electrode further comprises a mediator.

8. The method of claim 1, further comprising obtaining the monitored glucose level by an in vivo sensor comprising a plurality of electrodes including a working electrode comprising a mediator bonded to a polymer disposed on the working electrode.

9. The method of claim 1, wherein determining the unavailable values is based at least in part on the one or more stored values being corrupt, unusable, or unavailable.

10. An apparatus, comprising:

one or more processors; and

a memory storing instructions which, when executed by the one or more processors, cause the one or more processors to;

store a current value associated with a monitored glucose level;

retrieve one or more stored values associated with the monitored glucose level, including at least the current value and one or more prior values corresponding to measurements taken by an analyte sensor over a predetermined period of time;

determine a rate of change estimate based on the current value and the one or more prior values;

determine a number of unavailable values of the one or more stored values associated with the monitored glucose level;

calculate an uncertainty parameter associated with the determined rate of change estimate based on the number of unavailable values of the one or more stored values;

determine whether the uncertainty parameter is within a predetermined tolerance range;

when the uncertainty parameter is not within the predetermined tolerance range, discard the determined rate of change estimate; and

when the uncertainty parameter is within the tolerance range, assign the determined rate of change estimate to a selected bin of a plurality of predetermined bins, and display a trend arrow according to the selected bin.

11. The apparatus of claim 10, wherein the uncertainty parameter is dynamically configured according to a number of the one or more stored values available for determination of the rate of change estimate.

12. The apparatus of claim 10, storing instructions to calculate the uncertainty parameter at least based on a user specified parameter.

13. The apparatus of claim 10, wherein the predetermined tolerance range corresponds to an unacceptable number of the one or more stored values being corrupt, unusable or unavailable.

14. The apparatus of claim 10, wherein the monitored glucose level is obtained by an in vivo sensor comprising a plurality of electrodes including a working electrode comprising an analyte-responsive enzyme bonded to a polymer disposed on the working electrode.

15. The apparatus of claim 14, wherein the analyte-responsive enzyme is chemically bonded to the polymer.

16. The apparatus of claim 14, wherein the working electrode further comprises a mediator.

17. The apparatus of claim 10, wherein the monitored glucose level is obtained by an in vivo sensor comprising a plurality of electrodes including a working electrode comprising a mediator bonded to a polymer disposed on the working electrode.

18. The apparatus of claim 10, wherein the unavailable values are determined based at least in part on the one or more stored values being corrupt, unusable, or unavailable.