Methods, systems, and devices for real time execution and optimization of concurrent test protocols on a single device
First Claim
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1. A system for performing biological or chemical assays, comprising:
- a cartridge for receiving a sample from a single patient;
a sample processing device for receiving the cartridge and for containing a plurality of stations, an individual station configured to accept at least a portion of said sample and perform at least one subtask for the biological or chemical assay with said portion of said sample, wherein the sample processing device performs at least an analyte measurement, a blood analysis, and nucleic acid amplification; and
a controller that generates a schedule for subtasks performed simultaneously by said plurality of stations based oni) a comparison of the efficiency of said schedule as compared to the efficiency of a schedule in which input processes are scheduled sequentially, wherein a second schedule is determined to be more efficient than a first schedule where said second schedule requires less time, or fewer resources, or both, than said first schedule, andii) ii) anticipated availability of said plurality of stations, and that provides instructions that effects operations of said plurality of stations to perform said subtasks in accordance with said schedule;
wherein reagents are provided to the sample processing device through the cartridge without requiring reagents to be pumped into the device through tubes and/or tanks located outside of the cartridge and wherein the controller is provided with cartridge layout including where each test reagent is located in the cartridge wherein device resources comprises at least one or more pipettes and a centrifuge, wherein each device resource is further characterized by its operating characteristics and capabilities for the controller.
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Abstract
Provided herein are medical testing devices, systems, and methods that integrate multiplex, multi-technology, multi-configuration, multisample, or multi-threading capabilities. These capabilities are achieved using one or more of a level operations and communications architecture, a protocol execution engine, and a machine vision and processing system, method, or device in order to make testing of biologic or other samples more efficient in terms of cost, time, energy, or by prioritizing at least one other objective.
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20 Claims
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1. A system for performing biological or chemical assays, comprising:
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a cartridge for receiving a sample from a single patient; a sample processing device for receiving the cartridge and for containing a plurality of stations, an individual station configured to accept at least a portion of said sample and perform at least one subtask for the biological or chemical assay with said portion of said sample, wherein the sample processing device performs at least an analyte measurement, a blood analysis, and nucleic acid amplification; and a controller that generates a schedule for subtasks performed simultaneously by said plurality of stations based on i) a comparison of the efficiency of said schedule as compared to the efficiency of a schedule in which input processes are scheduled sequentially, wherein a second schedule is determined to be more efficient than a first schedule where said second schedule requires less time, or fewer resources, or both, than said first schedule, and ii) ii) anticipated availability of said plurality of stations, and that provides instructions that effects operations of said plurality of stations to perform said subtasks in accordance with said schedule; wherein reagents are provided to the sample processing device through the cartridge without requiring reagents to be pumped into the device through tubes and/or tanks located outside of the cartridge and wherein the controller is provided with cartridge layout including where each test reagent is located in the cartridge wherein device resources comprises at least one or more pipettes and a centrifuge, wherein each device resource is further characterized by its operating characteristics and capabilities for the controller. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A system for performing biological or chemical assays, comprising:
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a cartridge for receiving a sample from a single patient; a sample processing device for receiving the cartridge and for containing a plurality of stations, an individual station configured to accept at least a portion of said sample and perform at least one subtask for the biological or chemical assay with said portion of said sample, wherein the sample processing device performs at least an analyte measurement, a blood analysis, and nucleic acid amplification; and a controller that generates a schedule for subtasks performed simultaneously by said plurality of stations based on iii) a comparison of the efficiency of said schedule as compared to the efficiency of a schedule in which input processes are scheduled sequentially, wherein a second schedule is determined to be more efficient than a first schedule where said second schedule requires less time, or fewer resources, or both, than said first schedule, and iv) ii) anticipated availability of said plurality of stations, and that provides instructions that effects operations of said plurality of stations to perform said subtasks in accordance with said schedule; wherein reagents are provided to the sample processing device through the cartridge without requiring reagents to be pumped into the device through tubes and/or tanks located outside of the cartridge and wherein the controller is provided with cartridge layout including where each test reagent is located in the cartridge, wherein device resources comprises at least one or more pipettes and a centrifuge, wherein each device resource is further characterized by its operating characteristics and capabilities for the controller; said at least one of said stations comprises a detection station configured to collect information regarding the status of an individual biological or chemical assay and to utilize said information effective to maintain or modify said schedule of subtasks.
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20. A system for performing biological or chemical assays, comprising:
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a cartridge for receiving a sample from a single patient; a sample processing device for receiving the cartridge and for containing a plurality of stations, an individual station configured to accept at least a portion of said sample and perform at least one subtask for the biological or chemical assay with said portion of said sample, wherein the sample processing device performs at least an analyte measurement, a blood analysis, and nucleic acid amplification; and a controller that generates a schedule for subtasks performed simultaneously by said plurality of stations based on v) a comparison of the efficiency of said schedule as compared to the efficiency of a schedule in which input processes are scheduled sequentially, wherein a second schedule is determined to be more efficient than a first schedule where said second schedule requires less time, or fewer resources, or both, than said first schedule, and vi) ii) anticipated availability of said plurality of stations, and that provides instructions that effects operations of said plurality of stations to perform said subtasks in accordance with said schedule; wherein reagents are provided to the sample processing device through the cartridge without requiring reagents to be pumped into the device through tubes and/or tanks located outside of the cartridge and wherein the controller is provided with cartridge layout including where each test reagent is located in the cartridge, wherein device resources comprises at least one or more pipettes and a centrifuge, wherein each device resource is further characterized by its operating characteristics and capabilities for the controller; wherein the set of input processes are completed in less than the time required if the set of input processes were performed sequentially.
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Specification