Dry deposition of materials for microarrays using matrix displacement
First Claim
1. A method of dry dispensing components in a defined area on a surface comprising:
- (1) placing a solid in said area on said surface, wherein said solid comprises said components in a matrix;
(2) degrading said matrix of step (1);
(3) substantially removing matrix from the surface;
(4) retaining said components on said surface, wherein said retaining step uniformly adheres said components to said surface.
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Accused Products
Abstract
A method is disclosed which relates to the placement of binding partners on microarrays, where such binding partners contain proteins, nucleic acids, biological cells and other bio-reactive components. The present invention discloses uses and methods for manufacture of microarrays constructed in part by sectioning bundles of tubules or rods containing matrix immobilized bio-reactive molecules to produce large numbers of sample chips. The chips so produced are processed by deposition to microarrays. The deposited chips can then be manipulated to partition the immobilizing matrix away from the bio-reactive molecules contained in the matrix and to place said partitioned molecules onto various surfaces for subsequent analysis, to include binding assays, hybridization reactions, diagnostic methods and a variety of cell interaction-determining methodologies.
123 Citations
16 Claims
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1. A method of dry dispensing components in a defined area on a surface comprising:
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(1) placing a solid in said area on said surface, wherein said solid comprises said components in a matrix;
(2) degrading said matrix of step (1);
(3) substantially removing matrix from the surface;
(4) retaining said components on said surface, wherein said retaining step uniformly adheres said components to said surface. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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Specification