Osmotic delivery system, osmotic delivery system semipermeable body assembly, and method for controlling delivery rate of beneficial agents from osmotic delivery systems
First Claim
1. An osmotic delivery system plug for controlling a delivery rate of a beneficial agent in an osmotic delivery system, the plug comprising:
- a semipermeable body having;
a recess having an interior surface beginning at an opening in the body and ending at a depth surface within the semipermeable body;
a liquid contact surface located opposite the depth surface;
an outer surface located opposite the interior surface, the outer surface having means for sealing an environment of use from an inside of an enclosure of an osmotic delivery system in which the body is insertable;
a predetermined plug thickness defined by the location of the depth surface relative to the liquid contact surface; and
a predetermined wall width defined by the location of the outer surface relative to the interior surface, at least one of the predetermined plug thickness and predetermined wall width for controlling a rate of liquid permeation through the semipermeable body.
6 Assignments
0 Petitions
Accused Products
Abstract
Osmotic delivery system semipermeable body assemblies that control the delivery rate of a beneficial agent from an osmotic delivery system incorporating one of the semipermeable body assemblies. A semipermeable body assembly or plug includes a semipermeable body which is positionable in an opening of an osmotic delivery system. The semipermeable body has a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body. Because the beneficial agent in the osmotic delivery system is delivered at substantially the same rate the osmotic agent imbibes liquid which has permeated through the plug from a surrounding environment, the liquid permeation rate through the plug controls the delivery rate of the beneficial agent from the osmotic delivery system. The liquid permeation rate through a semipermeable body may be varied to control the delivery rate of beneficial agent from an osmotic delivery system by changing the thickness of the semipermeable body or by changing an amount of surface area of the semipermeable body that is exposed to liquid when the osmotic delivery system is located in a liquid environment of use.
54 Citations
62 Claims
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1. An osmotic delivery system plug for controlling a delivery rate of a beneficial agent in an osmotic delivery system, the plug comprising:
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a semipermeable body having;
a recess having an interior surface beginning at an opening in the body and ending at a depth surface within the semipermeable body;
a liquid contact surface located opposite the depth surface;
an outer surface located opposite the interior surface, the outer surface having means for sealing an environment of use from an inside of an enclosure of an osmotic delivery system in which the body is insertable;
a predetermined plug thickness defined by the location of the depth surface relative to the liquid contact surface; and
a predetermined wall width defined by the location of the outer surface relative to the interior surface, at least one of the predetermined plug thickness and predetermined wall width for controlling a rate of liquid permeation through the semipermeable body. - View Dependent Claims (2, 3, 4, 5, 6)
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7. An osmotic delivery system plug for controlling a delivery rate of a beneficial agent in an osmotic delivery system comprising:
a semipermeable body at least partially positionable in an opening in an enclosure of an osmotic delivery system, the semipermeable body including a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body, the liquid permeation rate for controlling a delivery rate of a beneficial agent in an osmotic delivery system. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23. An osmotic delivery system comprising:
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an enclosure having an opening and a delivery port, said enclosure having an interior holding a liquid swellable osmotic agent and a beneficial agent, said liquid swellable osmotic agent for imbibing liquid from a surrounding environment and causing a delivery rate of said beneficial agent from said enclosure;
a plug having a semipermeable body at least partially positioned in the opening, the semipermeable body including a hollow interior portion having a size selected to obtain a predetermined liquid permeation rate through the semipermeable body, the liquid permeation rate for controlling the delivery rate of the beneficial agent in the osmotic delivery system. - View Dependent Claims (24, 25, 26, 27, 28, 29)
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30. A method of controlling a delivery rate of a beneficial agent from an osmotic drug delivery system that includes an enclosure having an interior holding a liquid swellable osmotic agent and a beneficial agent, the osmotic drug delivery system also including a plug having a semipermeable body at least partially positioned in an opening of an enclosure, the semipermeable body including a hollow interior portion, the method comprising the steps of:
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determining a desired delivery rate of the beneficial agent;
selecting a plug with a hollow interior portion sized to obtain a predetermined liquid permeation rate through the semipermeable body corresponding to the desired delivery rate of the beneficial agent;
positioning the plug at least partially within the opening of the enclosure; and
locating the osmotic drug delivery system in an environment of use. - View Dependent Claims (31)
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32. A method of changing a liquid permeation rate through a semipermeable body of an osmotic delivery system to increase a delivery rate of a beneficial agent from the osmotic delivery system, the method comprising the steps of:
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making a semipermeable body having a liquid permeability coefficient and a thickness; and
changing said thickness of said semipermeable body to alter a liquid permeation rate through said semipermeable body. - View Dependent Claims (33, 34, 35, 36, 37, 38)
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- 39. A method of varying a liquid permeation rate through a semipermeable body of an osmotic delivery system in which a liquid impermeable sleeve is mounted on the semipermeable body to vary a delivery rate of a beneficial agent from said osmotic delivery system, the method comprising the step of moving said liquid impermeable sleeve along an exterior surface of said semipermeable body to vary an amount of surface area of said exterior surface that is immediately exposed to liquids when said osmotic delivery system is located in a liquid environment of use.
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42. A method of varying a liquid permeation rate through a semipermeable body of an osmotic delivery system to vary a delivery rate of a beneficial agent from the osmotic delivery system, the method comprising the step of:
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selecting a desired liquid permeation rate through the semipermeable body of the osmotic delivery system; and
providing a plurality of semipermeable body elements in abutting relation to one another to define said semipermeable body and to achieve said selected liquid permeation rate. - View Dependent Claims (43, 44, 45)
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46. An osmotic delivery system comprising:
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a liquid impermeable enclosure having an interior holding a beneficial agent and an osmotic agent for imbibing liquid from a surrounding environment and causing delivery of said beneficial agent from said liquid impermeable enclosure;
a semipermeable body in liquid communication with said liquid impermeable enclosure for permitting liquid to permeate through said semipermeable body to said osmotic agent;
a liquid impermeable sleeve separate from said liquid impermeable enclosure and surrounding a portion of a surface of said semipermeable body such that said portion of said surface is not immediately exposed to liquid when said osmotic delivery system is located in a liquid environment of use and such that said semipermeable body includes an exposure surface defined by an area of said surface that is not surrounded by said liquid impermeable sleeve and is immediately exposed to liquids when said osmotic delivery system is located in the liquid environment of use. - View Dependent Claims (47, 48, 49, 50, 51, 52)
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53. An osmotic delivery system comprising:
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an enclosure having an interior holding a beneficial agent and an osmotic agent, said osmotic agent for imbibing liquid from a surrounding environment and causing delivery of said beneficial agent from said enclosure;
a first semipermeable body in liquid communication with said enclosure for permitting liquid to permeate through said first semipermeable body to said osmotic agent; and
a second semipermeable body abutting said first semipermeable body and in liquid communication with said first semipermeable body so as to permit liquid to permeate through said first semipermeable body and said second semipermeable body to said osmotic agent. - View Dependent Claims (54, 55, 56)
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57. An osmotic delivery system comprising:
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an enclosure having an opening and a delivery port, said enclosure having an interior holding a liquid swellable osmotic agent and a beneficial agent, said liquid swellable osmotic agent for imbibing liquid from a surrounding environment and causing a delivery rate of said beneficial agent from said enclosure; and
a plug having a semipermeable body, the plug being at least partially positioned in the opening, the semipermeable body having an exposure surface that is immediately exposed to liquids when the osmotic delivery system is located in a liquid environment of use, said exposure surface including a conical surface. - View Dependent Claims (58, 59, 60, 61, 62)
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Specification