System and method for treating eye and nerve diseases in diabetic and non-diabetic patients

• US 20010056064A1
• Filed: 06/15/2001
• Published: 12/27/2001
• Est. Priority Date: 06/16/2000
• Status: Active Grant

• Current Assignee: Thomas T. Aoki
• Original Assignee: Thomas T. Aoki
• Inventors: Aoki, Thomas T.
• Granted Patent: US 6,613,736 B2
• Time in Patent Office: Days
• US Class Current: 514/6.5
• CPC Class Codes: A61K 38/28 Insulins
• CPC Class Codes: Y10S 530/849 Eyes; vessels; umbilical cord

Abstract

The present invention is a system and method capable of increasing retinal and neural glucose oxidation by enhancing pyruvate dehydrogenase activity and therefore treats retinopathy and central nervous system disorders in both diabetic and non-diabetic patients. The current invention is a system and method of the treating of eye and nerve diseases using insulin pulses to a patient utilizing Chronic Intermittent Intravenous Insulin Therapy to achieve an increase in retinal and neural glucose oxidation by enhancing pryuvate dehydrogenase activity, therefore treating retinopathy and central nervous system disorders in both diabetic and non-diabetic patients.

Claims

1. A system for treating eye and nerve diseases in diabetic and non-diabetic patients through an intravenous site administering a pulse of insulin to a patient comprising:

a) a means for determining a respiratory quotient of the patient,

b) a liquid or food containing glucose, the liquid or food containing glucose being consumed by the patient, and

c) a means for administering intravenously the pulse of insulin at a regular interval of time until the respiratory quotient is 0.90 or greater.

2. The system of

claim 1

, wherein the intravenous site further comprises a needle or catheter located in the patient'"'"'s body, hand or forearm.

3. The system of

claim 1

, wherein the liquid or food contains 60 to 100 grams of glucose.

4. The system of

claim 1

, wherein the means for administering the pulse of insulin is an intravenous infusion device.

5. The system of

claim 1

, wherein the interval of time is about six minutes.

6. The system of

claim 1

, wherein the pulse of insulin is tailored to achieve increased retinal and neural glucose oxidation by enhanced pyruvate dehydrogenase complex activity.

7. The system of

claim 1

, wherein the intravenous site is converted to a heparin or a saline lock when the administration of insulin pulses has temporarily ceased between treatments.

8. A method for treating eye and nerve diseases in diabetic and non-diabetic patients through an intravenous site administering a pulse of insulin to a patient comprising the steps of:

a) determining a respiratory quotient of the patient,

b) having the patient consume a liquid or food containing glucose,

c) administering intravenously the pulse of insulin at a regular interval of time until the respiratory quotient is 0.90 or greater,

d) providing the patient a rest period, and

e) repeating the steps a-d three times.

9. The method of

claim 8

, wherein the intravenous site further comprises a needle or catheter located in the patient'"'"'s body, hand or forearm.

10. The method of

claim 8

, wherein the liquid or food contains 60 to 100 grams of

11. The method of

claim 8

, wherein the pulse of insulin is administered by an intravenous infusion device.

12. The method of

claim 8

, wherein the interval of time is about six minutes.

13. The method of

claim 8

, wherein the pulse of insulin is tailored to achieve increased retinal and glucose oxidation by enhanced pyruvate dehydrogenase complex activity.

14. The method of

claim 8

, wherein the intravenous site is converted to a heparin or a

15. The method of

claim 8

, wherein the rest period is one hour.

16. The method of

claim 8

, wherein said steps a-e are repeated at least once a week.

17. The method of

claim 8

, wherein said steps a-e are repeated three or more times a week.