DOSAGE FORM COMPRISING MEANS FOR CHANGING DRUG DELIVERY SHAPE

• US 20020006439A1
• Filed: 08/05/1998
• Published: 01/17/2002
• Est. Priority Date: 09/09/1997
• Status: Active Grant

• Current Assignee: David E. Edgren, Robert R. Skluzacek
• Original Assignee: David E. Edgren, Robert R. Skluzacek
• Inventors: EDGREN, DAVID E., SKLUZACEK, ROBERT R.
• Granted Patent: US 6,514,530 B2
• Time in Patent Office: Days
• US Class Current: 424/464
• CPC Class Codes: A61K 9/0004 Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas

Abstract

A dosage form is disclosed comprising means for delivering essentially a total dose of drug.

Claims

1. A dosage form for delivering a drug to a patient in need of the drug, wherein the dosage form comprises:

an orally administrable therapeutic composition comprising a dose of drug and a pharmaceutically acceptable polymer carrier for transporting the drug from the dosage form;

a membrane that surrounds the therapeutic composition, which membrane comprises a polymer permeable to the passage of fluid, a plasticizer, a surfactant, and a binder; and

an exit in the membrane for delivering the drug at a sustained-release rate over an extended time.

2. The dosage form for delivering the drug according to claim 1, wherein the membrane changes shape during the operation of the dosage form.

3. A dosage form for delivering the drug according to claim 1, wherein the binder is compatible with and binds the polymer, plasticizer, and surfactant into the membrane.

5. The dosage form for delivering the drug according to claim 3, wherein the membrane possesses a surface that faces the therapeutic composition and the displacement composition and a surface that faces the patient and carries thereon a dose of drug.

4. The dosage form for delivering a drug to a patient in need of the drug, wherein the dosage form comprises:

an orally administrable therapeutic composition comprising a dose of drug and a pharmaceutically acceptable polymer carrier for transporting the drug from the dosage form;

a displacement composition comprising a polymer that expands in the presence of an aqueous fluid and thereby pushes the therapeutic composition from the dosage form;

a membrane that surrounds the therapeutic composition and the displacement composition, which membrane comprises a polymer permeable to the passage of an aqueous fluid, a plasticizer, a surfactant, and a binder; and

an exit in the membrane for delivering the drug at a sustained-release rate over an extended time.