Method of inhibiting angiogenesis using active vitamin D analogues
First Claim
1. A method of inhibiting angiogenesis associated with malignant or neoplastic cells, comprising treating the cells with an effective amount of a hypocalcemic hydroxy vitamin D compound having a hydrocarbon moiety at the C24 position, the cells being cancers of the breast, colon, prostate, testes, lung, neck and head, pancreas, endometrium, bladder, cervix, ovaries, squamous cell carcinomas, myeloid and lymphocytic leukemia, lymphoma, medullary thyroid carcinoma, melanoma, multiple myeloma, retinoblastoma or sarcomas of the soft tissues and bone.
1 Assignment
0 Petitions
Accused Products
Abstract
Methods utilizing active vitamin D analogs for the inhibition of angiogenesis associated with malignant and neoplasmic cells. Methods comprise the application of an effective amount of a hypocalcemic vitamin D compound to inhibit the angiogenesis of malignant cells, inducing the apoptosis of malignant cells, and regressing the growth of tumorous cells.
7 Citations
34 Claims
-
1. A method of inhibiting angiogenesis associated with malignant or neoplastic cells, comprising treating the cells with an effective amount of a hypocalcemic hydroxy vitamin D compound having a hydrocarbon moiety at the C24 position, the cells being cancers of the breast, colon, prostate, testes, lung, neck and head, pancreas, endometrium, bladder, cervix, ovaries, squamous cell carcinomas, myeloid and lymphocytic leukemia, lymphoma, medullary thyroid carcinoma, melanoma, multiple myeloma, retinoblastoma or sarcomas of the soft tissues and bone.
- 2. A method of inhibiting angiogenesis associated with malignancy or neoplasm in a subject in need thereof, comprising administering to the subject an effective amount of a hypocalcemic vitam,in D compound represented by formula I:
- 22. A method of treating a human to inhibit angiogenesis associated with breast cancer, colon cancer, prostate cancer, testicular cancer, pancreatic cancer, endometrial cancer, small cell and non-small cell cancer of the lung (including squamous, adneocarcinoma and large cell types), squamous cell of the head and neck, bladder, ovarian and cervical cancers, myeloid and lymphocyltic leukemia, lymphoma, hepatic tumors, medullary thyroid carcinoma, multiple myeloma, melanoma, retinoblastoma or sarcomas of the soft tissue and bone, comprising administering to the human an effective amount of a hypocalcemic vitamin D compound.
-
26. A method of treating a human to inhibit angiogenesis associated with malignant cells, comprising administering to the patient a hypocalcemic vitamin D compound and a cytotoxic agent.
-
33. A method of inducing apoptosis of malignant or neoplastic cells, comprising treating the cells with an effective amount of a hypocalcemic vitamin D compound, the cells being cancers of the breast, colon, prostate, testes, lung, neck and head, pancreas, endometrium, bladder, cervix, ovaries, squamous cell carcinoma, myeloid and lymphocytic leukemia, lymphoma, medullary thyroid carcinoma, melanoma, multiple myeloma, retinoblastoma or sarcomas of the soft tissues and bone.
-
34. A method of inducing the regression of tumor cells comprising treating the cells with an effective amount of a hypocalcemic vitamin D compound, the cells being cancers of the breast, colon, prostate, testes, lung, neck and head, pancreas, endometrium, bladder, cervix, ovaries, squamous cell carcinoma, myeloid and lymphocytic leukemia, lymphoma, medullary thyroid carcinoma, melanoma, multiple myeloma, retinoblastoma or sarcomas of the soft tissues and bone.
Specification