Oxygenator of hollow fiber membrane type

• US 20020039543A1
• Filed: 12/14/2000
• Published: 04/04/2002
• Est. Priority Date: 12/15/1999
• Status: Active Grant

• Current Assignee: Terumo Kabushiki Kaisha
• Original Assignee: Terumo Kabushiki Kaisha
• Inventors: Takeuchi, Kazuhiko, Ikeda, Tomohiko
• Granted Patent: US 6,503,451 B2
• Time in Patent Office: Days
• US Class Current: 422/48
• CPC Class Codes: A61M 1/1698 Blood oxygenators with or without heat-exchangers intracorporal A61M1/1678; manufacturing of membranes therefor B01D67/00; semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi-permeable membranes characterised by their material B01D71/00
• CPC Class Codes: A61M 1/3623 Means for actively controlling temperature of blood
• CPC Class Codes: B01D 63/02 Hollow fibre modules
• CPC Class Codes: B01D 63/021 Manufacturing thereof
• CPC Class Codes: B01D 63/0233 forming the bundle
• CPC Class Codes: B01D 63/025 Bobbin units
• CPC Class Codes: B01D 63/034 Lumen open in more than two directions

Abstract

An oxygenator of hollow fiber membrane type of the present invention includes a cylindrical core; a cylindrical hollow fiber membrane bundle consisting of a plurality of gas-exchange hollow fiber membranes wound on an outer surface of the cylindrical core; a housing accommodating the cylindrical hollow fiber membrane bundle; a gas inlet portion and a gas outlet portion both communicating with the interior of the hollow fiber membrane; and a blood inlet portion and a blood outlet portion communicating with the outside of the hollow fiber membrane and the interior of the housing. The hollow fiber membranes of the cylindrical hollow fiber membrane bundle wound on cylindrical core are multi-layered on the outer surface thereof. Each hollow fiber membrane layer has cross portions of the hollow fiber membranes in the neighborhood of the center of the cylindrical core in a longitudinal direction thereof. Positions of the cross portions of each of the respective hollow fiber membrane layers are differentiated from one another to prevent contact between the cross portions of the hollow fiber membrane layers laminated on each other.

Claims

1. An oxygenator of hollow fiber membrane type comprising a cylindrical core;

a cylindrical hollow fiber membrane bundle consisting of a plurality of gas-exchange hollow fiber membranes wound on an outer surface of said cylindrical core;

a housing accommodating said cylindrical hollow fiber membrane bundle;

a gas inlet portion and a gas outlet portion both communicating with the interior of said hollow fiber membranes; and

a blood inlet portion and a blood outlet portion communicating with the outside of said hollow fiber membranes and the interior of said housing,

wherein said hollow fiber membranes of said cylindrical hollow fiber membrane bundle are multi-layered on the outer surface of said cylindrical core;

each hollow fiber membrane layer has cross portions of the hollow fiber membranes in the neighborhood of a center of said cylindrical core in the longitudinal direction thereof and positions of said cross portions of each of said respective hollow fiber membrane layers are differentiated from one another to prevent contact between said cross portions of said hollow fiber membrane layers laminated on each other or to prevent contact between said cross portion of another hollow fiber membrane layer and cross portions of two hollow fiber membrane layers laminated on each other.

2. An oxygenator of hollow fiber membrane type according to claim 1, wherein a position of said cross portion changes continuously.

3. An oxygenator of hollow fiber membrane type according to claim 1, wherein a positions of said cross portion changes stepwise.

4. An oxygenator of hollow fiber membrane type according to claim 1, wherein a maximum interval between said cross portions is in the range of 2%-75% of a length of said hollow fiber membrane bundle in a longitudinal direction thereof.

5. An oxygenator of hollow fiber membrane type according to claim 1, wherein all of said cross portions are disposed within a width of 80 mm with respect to the center of a cylindrical core in a longitudinal direction thereof.

6. An oxygenator of hollow fiber membrane type according to claim 1, wherein a maximum interval between said cross portions is in the range of 3mm-80 mm.

7. An oxygenator of hollow fiber membrane type according to claim 1, wherein said cross portions are continuously formed by winding two to six hollow fiber membranes in substantially parallel with one another and with adjacent ones spaced at substantially regular intervals on a cylindrical core such that adjacent winds of said hollow fiber membranes cross each other.

8. An oxygenator of hollow fiber membrane type according to claim 1, wherein said oxygenator of hollow fiber membrane type has a cylindrical heat exchanging part accommodated in said cylindrical core.

9. An oxygenator of hollow fiber membrane type according to claim 1, wherein said oxygenator has two partitioning walls for fixing both ends of said cylindrical hollow fiber membrane bundle to said housing;

and a gas inlet port and a gas outlet port both communicating with an interior of said hollow fiber membrane.

10. An oxygenator of hollow fiber membrane type according to claim 1, wherein said hollow fiber membrane bundle is formed by winding one or a plurality of hollow fiber membranes simultaneously and spirally on a cylindrical core with adjacent hollow fiber membranes spaced at substantially regular intervals;

and

in winding said hollow fiber membranes on said cylindrical core, a cylindrical core-rotating means and a winder for weaving said hollow fiber membranes are operated, based on a computation equation (1) shown below and make a continuous relative movement in the range of 40 mm+40 mm in an axial direction of said cylindrical core supposing that the center of said cylindrical core in a longitudinal direction thereof is 0;

traverse [mm/lot]×

n(integer and 2 or more)=traverse width×

2±

(outer diameter of fiber+interval between adjacent fibers×

number of fibers to be wound  

 

computation equation (1).

11. An oxygenator of hollow fiber membrane type according to claim 10, wherein in the relative movement of said cylindrical core-rotating means and said winder in the axial direction of said cylindrical core, said winder moves with said cylindrical core-rotating means fixed or said cylindrical core-rotating means moves with said winder fixed.

12. An oxygenator of hollow fiber membrane type according to claim 1, wherein said oxygenator has a first blood chamber formed inside the cylindrical core and communicating to the blood inlet portion and a second blood chamber formed between said housing and an outer surface of the hollow fiber membrane bundle and communicating to the blood outlet portion, and said cylindrical core is a plurality of grooves forming a blood duct between an outer surface of the cylindrical core and an inner surface of the cylindrical hollow fiber membrane bundle and blood-circulating openings communicating the groove to said first blood chamber

13. An oxygenator of hollow fiber membrane type according to claim 1, wherein said cylindrical core has a plurality of circular arc-shaped grooves substantially parallel with one another and a ungrooved portion having a flat surface and extending on almost the entirety of a portion forming said grooves of the cylindrical core.