Antimicrobial compositions containing quaternary ammonium compounds, silanes and other disinfectants with furanones

• US 20020111282A1
• Filed: 11/08/2001
• Published: 08/15/2002
• Est. Priority Date: 11/17/2000
• Status: Active Grant

• Current Assignee: SC Johnson & Son Incorporated
• Original Assignee: SC Johnson & Son Incorporated
• Inventors: Charaf, Ursula K., Avery, Richard W.
• Granted Patent: US 6,528,472 B2
• Time in Patent Office: Days
• US Class Current: 510/130
• CPC Class Codes: A01N 2300/00 Combinations or mixtures of active ingredients covered by classes A01N27/00 - A01N65/48 with other active or formulation relevant ingredients, e.g. specific carrier materials or surfactants, covered by classes A01N25/00 - A01N65/48
• CPC Class Codes: A01N 33/12 Quaternary ammonium compounds
• CPC Class Codes: A01N 43/08 with oxygen as the ring hetero atom
• CPC Class Codes: A01N 47/44 Guanidine; Derivatives thereof
• CPC Class Codes: A01N 55/00 Biocides, pest repellants or attractants, or plant growth regulators, containing organic compounds containing elements other than carbon, hydrogen, halogen, oxygen, nitrogen and sulfur containing organo-phosphorus compounds A01N57/00

Abstract

A synergistic antimicrobial composition includes an effective amount of at least one furanone, together with other disinfectants, such as, for example, an effective amount of at least one organosilane with quaternary ammonium functionality, and/or an effective amount of at least one quaternary ammonium compound. Additionally, biguanides and disinfectant amines also may be advantageously combined with furanones in an antimicrobial composition.

Claims

1. A composition comprising:

(a) a sparing amount of at least one furanone; and

(b) a sparing amount of at least one stable quaternized organosilane,

wherein the amount of each of components (a) and (b) is sufficient to form, in combination, a synergistic, antimicrobial composition.

2. The composition of claim 1, wherein the quaternized organosilane is stabilized using one or more components selected from the group consisting of a solvent, a quaternary ammonium compound, a saccharide-based surfactant, a nonionic surfactant, an amphoteric surfactant, a sarcosine-based surfactant, and a cationic surfactant.

5. The composition of claims 1, 3 or 4, wherein the sparing amount of furanone is between about 1 μ

g/L and about 5000 mg/L of the composition.

6. The composition of claims 1 or 4, wherein the sparing amount of quaternized organosilane is between about 0.001 weight percent and about 5.0 weight percent of the composition.

8. The composition of claims 1, 3 or 4, wherein the composition is effective against microorganisms selected from the group consisting of a fungus, a yeast, a bacterium, and mixtures thereof.

9. The composition of claim 8, wherein the fungus is selected from the group consisting of Alternaria alternata, Aureobasidium pullullans, Cladosporium cladosporioides and Penicillium digitatum.

10. The composition of claim 8, wherein the yeast is Candida albicans.

11. The composition of claim 8, wherein the bacterium is Staphylococcus aureus.

12. The composition of claims 1, 3 or 4, wherein the at least one furanone is Furanone 30.

13. The composition of claims 1 or 4, wherein the at least one quaternized organosilane is selected from the group consisting of 3-(trimethoxysilyl)propyldimethyl-octadecyl ammonium chloride and 3-(trimethoxysilyl)propylmethyl-di(decyl) ammonium chloride.

16. The composition of claim 15, further comprising one or more ingredients selected from the group consisting of:

water, a sequestering or complexing agent, a fragrance, an additional disinfectant, and a pH adjustor.

3. A composition comprising:

(a) a sparing amount of at least one furanone; and

(b) a sparing amount of at least one quaternary ammonium compound,

wherein the amount of each of components (a) and (b) is sufficient to form, in combination, a synergistic antimicrobial composition.

7. The composition of claims 3 or 4, wherein the sparing amount of quaternary ammonium compound is between about 0.01 weight percent and about 10.0 weight percent of the composition.

14. The composition of claims 3 or 4, wherein the at least one quaternary ammonium compound is selected from the group consisting of didecyl dimethyl ammonium chloride, dioctyl dimethyl ammonium chloride, octyl decyl dimethyl ammonium chloride, benzalkonium chloride and alkyl benzyl alkyl dimethyl ammonium chloride.

4. A composition comprising:

(a) a sparing amount of at least one furanone;

(b) a sparing amount of at least one quaternized organosilane; and

(c) a sparing amount of at least one quaternary ammonium compound,

wherein the amount of each of components (a), (b) and (c) is sufficient to form, in combination, a synergistic antimicrobial composition.

15. A composition comprising:

(a) a sparing amount of at least one furanone; and

(b) a sparing amount of at least one disinfectant selected from the group consisting of a quaternized organosilane, a quaternary ammonium compound, a disinfectant amine, and a biguanide,

wherein, the amount of each of components (a) and (b) is sufficient to form, in combination, a synergistic antimicrobial composition.

17. A method of cleaning a surface, or a reservoir or conduit that is fluid-filled comprising:

providing a synergistic antimicrobial composition comprising;

(a) a sparing amount of at least one furanone; and

(b) a sparing amount of at least one stable quaternized organosilane; and

applying the composition to the surface, reservoir, or conduit to be cleaned.

20. The method of claims 17, 18 or 19, wherein the sparing amount of the at least one furanone is between about 1.0×

10<sup>−

7</sup> weight percent and about 0.5 weight percent of the composition.

21. The method of claims 17 or 19, wherein the sparing amount of the at least one quaternized organosilane is between about 0.001 weight percent and about 5.0 weight percent of the composition.

23. The method of claims 17, 18 or 19, wherein the at least one furanone is Furanone 30.

24. The method of claims 17 or 19, wherein the at least one quaternized organosilane is 3-(trimethoxysilyl)propyl-dimethyl-octadecyl ammonium chloride.

18. A method of cleaning a surface, or a reservoir or conduit that is fluid-filled comprising:

providing a synergistic antimicrobial composition comprising;

(a) a sparing amount of at least one furanone; and

(b) a sparing amount of at least one quaternary ammonium compound; and

applying the composition to the surface, reservoir, or conduit to be cleaned.

22. The method of claims 18 or 19, wherein the sparing amount of the at least one quaternary ammonium compound is between about 0.01 weight percent and about 10.0 weight percent of the composition.

25. The method of claims 18 or 19, wherein the at least one quaternary ammonium compound is selected from the group consisting of didecyl dimethyl ammonium chloride and benzalkonium chloride.

19. A method of cleaning a surface, or a reservoir or conduit that is fluid-filled comprising:

providing a synergistic antimicrobial composition comprising;

(a) a sparing amount of at least one furanone;

(b) a sparing amount of at least one quaternized organosilane; and

(c) a sparing amount of at least one quaternary ammonium compound; and

applying the composition to the surface, reservoir, or conduit to be cleaned.

26. A method of cleaning a surface, or a reservoir or conduit that is fluid-filled comprising:

providing a synergistic antimicrobial composition comprising;

(a) a sparing amount of at least one furanone; and

(b) a sparing amount of at least one disinfectant selected from the group consisting of a quaternized organosilane, a quaternary ammonium compound, a disinfectant amine, and a biguanide, and

applying the composition to the surface, reservoir, or conduit to be cleaned.