Microfluidic devices and systems incorporating cover layers

• US 20020127149A1
• Filed: 05/01/2001
• Published: 09/12/2002
• Est. Priority Date: 02/24/1998
• Status: Active Grant

• Current Assignee: Colin B. Kennedy, Robert Nagle, Robert S. Dubrow
• Original Assignee: Colin B. Kennedy, Robert Nagle, Robert S. Dubrow
• Inventors: Kennedy, Colin B., Dubrow, Robert S., Nagle, Robert
• Granted Patent: US 6,488,897 B2
• Time in Patent Office: Days
• US Class Current: 422/102
• CPC Class Codes: B01L 2200/025 Align devices or objects to ensure defined positions relative to each other
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2200/0605 Metering of fluids
• CPC Class Codes: B01L 2200/0689 Sealing
• CPC Class Codes: B01L 2300/0681 Filter
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2300/16 Surface properties and coatings
• CPC Class Codes: B01L 2400/0406 capillary forces
• CPC Class Codes: B01L 2400/0415 electrical forces, e.g. electrokinetic
• CPC Class Codes: B01L 2400/0487 fluid pressure, pneumatics
• CPC Class Codes: B01L 3/502715 characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
• CPC Class Codes: B01L 3/5085 for multiple samples, e.g. microtitration plates
• CPC Class Codes: G01N 2035/00148 Test cards, e.g. Biomerieux or McDonnel multiwell test cards
• CPC Class Codes: G01N 27/44791 Microapparatus sample containers with integrated microfluidic structures B01L3/5027
• CPC Class Codes: Y10T 436/25 including sample preparation
• CPC Class Codes: Y10T 436/25625 Dilution
• CPC Class Codes: Y10T 436/2575 Volumetric liquid transfer

Abstract

The present invention provides microfluidic devices that comprise a body structure comprising at least a first microscale channel network disposed therein. The body structure has a plurality of ports disposed in the body structure, where each port is in fluid communication with one or more channels in the first channel network. The devices also include a cover layer comprising a plurality of apertures disposed through the cover layer. The cover layer is mated with the body structure whereby each of the apertures is aligned with a separate one of the plurality of ports.

Claims

1. A microfluidic device, comprising:

a body structure comprising at least a first microscale channel network disposed therein, the body structure having a plurality of ports disposed in the body structure, each port being in fluid communication with one or more channels in the first channel network; and

a cover layer comprising a plurality of apertures disposed through the cover layer, the cover layer being mated with the body structure whereby each of the apertures is aligned with at least one of the plurality of ports.